Trial reportWorld journal of pediatrics : WJP2019
Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder.
Trial report in World journal of pediatrics : WJP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04284059 (Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Pooled it
- Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age.The Cochrane database of systematic reviews · 2020Pooled it
- Vitamin D and Child Neurodevelopment-A Post Hoc Analysis.Nutrients · 2023Trial
- Vitamin D and Vitamin BDiseases (Basel, Switzerland) · 2026Review
- Investigating the Impact of Nutrition and Oxidative Stress on Attention Deficit Hyperactivity Disorder.Nutrients · 2024Review
- The Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews.Current behavioral neuroscience reports · 2024Article
- Vitamin D Status and Behavioral Impulsivity in Anorexia Nervosa: Insights from a Longitudinal Study.Nutrients · 2024Article
- The influence of multivitamins on neurological and growth disorders: a cross-sectional study.Frontiers in nutrition · 2024Article
- Appraising the role of circulating concentrations of micronutrients in attention deficit hyperactivity disorder: a Mendelian randomization study.Scientific reports · 2023Article
- The Synaptic and Circuit Functions of Vitamin D in Neurodevelopment Disorders.Neuropsychiatric disease and treatment · 2023Review
- Article
- Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders.Nutrients · 2022Review
- Review
- Vitamin D Status in Children with Autism Spectrum Disorders: Determinants and Effects of the Response to Probiotic Supplementation.Metabolites · 2022Article
- Article
- Vitamin D levels in children with attention deficit hyperactivity disorder: Association with seasonal and geographical variation, supplementation, inattention severity, and theta:beta ratio.Biological psychology · 2021Article
- Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders.Open biology · 2020Review
- Use of Non-Pharmacological Supplementations in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Critical Review.Nutrients · 2020Review
- Complementary and alternative medicine in ADHD treatment: more soundly designed clinical trials needed.World journal of pediatrics : WJP · 2019Article
- Review
Corrections and comments
- Commented on by
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this research the symptom improvement of attention-deficit hyperactivity disorder (ADHD) of children was assessed by oral vitamin D administration in Tabriz, Iran.
methodsIn this double-blind, randomized clinical trials, 96 children (2-18 years) were enrolled to placebo and vitamin D groups. Children took vitamin D pearl (50,000 IU/week) or placebo for 6 weeks. Children, who had the change in methylphenidate dosage and received any anticonvulsants and corticosteroids were excluded from the research. ADHD symptoms were diagnosed by Conners parent rating scale (CPRS) test at baseline and after intervention. ADHD Conners divided into inattention (IA), hyperactivity/impulsivity (H/I) and combination type (C) subscales. Vitamin D serum level was assessed at baseline and after 8 weeks in both groups.
resultsThe differences between CPRS and its subscales were not significant at baseline (P > 0.05). The Conners IA score was decreased in vitamin D group (P < 0.05; adjusted with age and baseline values). ADHD Conners and all subscale scores reduced remarkably after intervention in patients with insufficient level of vitamin D compared to placebo (P < 0.05).
conclusionsOral vitamin D improved ADHD symptoms with a particular effect on inattention symptoms. In addition, symptoms related to all subscales were improved remarkably in patients with insufficient level of vitamin D. Vitamin D treatment in children with ADHD could be considered due to the expand benefit of vitamin D in body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.