ArticlePsychopharmacology2019
Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Improving Clinical, Cognitive, and Psychosocial Dysfunctions in Patients with Schizophrenia: A Neurofeedback Randomized Control Trial.Neural plasticity · 2021Trial
- Schizophrenia: from mechanism to therapy.Science China. Life sciences · 2026Review
- Could brain-derived neurotrophic factor, irisin, and peroxisome proliferator-activated receptor-gamma be a pathway in cognitive impairment in schizophrenia?BMC psychiatry · 2026Article
- Combination of UGT1A1 polymorphism and baseline plasma bilirubin levels in predicting the risk of antipsychotic-induced dyslipidemia in schizophrenia patients.Schizophrenia (Heidelberg, Germany) · 2024Article
- Sex differences in the association between Body Mass Index and cognitive function in Parkinson disease: a cross-sectional study.Frontiers in nutrition · 2024Article
- The Influence of Electroconvulsive Therapy (ECT) on Brain-Derived Neurotrophic Factor (BDNF) Plasma Level in Patients with Schizophrenia-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Gender differences in prevalence and associated factors of metabolic syndrome in first-treatment and drug-naïve schizophrenia patients.Annals of general psychiatry · 2023Article
- Sex differences in the prevalence and clinical correlates of diabetes in Chinese patients with chronic schizophrenia.Heliyon · 2023Article
- Brain-derived neurotrophic factor (BDNF) in schizophrenia research: a quantitative review and future directions.AIMS neuroscience · 2023Review
- Pattern of long-term weight and metabolic changes after a first episode of psychosis: Results from a 10-year prospective follow-up of the PAFIP program for early intervention in psychosis cohort.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Sex Differences in Obesity and Cognitive Function in Chinese Elderly Patients With Chronic Schizophrenia.Frontiers in endocrinology · 2022Article
- Understanding the Effects of Antipsychotics on Appetite Control.Frontiers in nutrition · 2021Review
- Sex Differences in the Association of HOMA-IR Index and BDNF in Han Chinese Patients With Chronic Schizophrenia.Frontiers in psychiatry · 2021Article
- Cannabis use influence on peripheral brain-derived neurotrophic factor levels in antipsychotic-naïve first-episode psychosis.European archives of psychiatry and clinical neuroscience · 2020Article
- Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia.Scientific reports · 2020Article
- Brain-derived neurotrophic factor and mental disorders.Biomedical journal · 2020Review
- Effect of Exercise on Major Depressive Disorder and Schizophrenia: A BDNF Focused Approach.Noro psikiyatri arsivi · 2019Review
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
Abstract
RATIONALE AND
objectiveSchizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex differences in the relationship between serum BDNF levels and obesity in patients with chronic schizophrenia.
methodsWe recruited 132 Chinese patients with chronic schizophrenia (98 males and 34 females) and compared sex differences in the body mass index (BMI), obesity, serum BDNF levels, and their associations. Psychopathology symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). A regression model with various demographic and clinical variables was applied to predict the serum levels of BDNF.
resultsFemale patients had a higher rate of obesity and higher BMI, but lower BDNF levels than male schizophrenia patients. A significantly negative correlation was observed between BMI and BDNF levels only in female patients but not in male patients. The multiple regression model with demographic and clinical variables significantly predicted BDNF levels only in female patients, with a medium size effect. And only in female patients, BMI made a significant contribution to this prediction.
conclusionOur results indicate significant sex differences in the obesity, BMI, BDNF levels, and their association in chronic patients with schizophrenia, showing a significant inverse correlation between BMI and BDNF levels only in female patients. Thus, sex needs to be considered when assessing the relationship between BDNF and metabolic syndromes in schizophrenia.
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