Evidence map›Paper›PMID 30456498›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020

Higher incidence of vasodilator-induced left ventricular cavity dilation by PET when compared to treadmill exercise-ECHO in hypertrophic cardiomyopathy.

Dai-Yin Lu, Hulya Yalçin, Sanjay Sivalokanathan, Gabriela V Greenland, Nestor Vasquez, Fatih Yalçin, Min Zhao, Ines Valenta, Peter Ganz, Miguel Hernandez Pampaloni and 4 more

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2020: positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Review
  7. Transient ischemic dilation in hypertrophic cardiomyopathy: A complex sign in a complex disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Dai-Yin LuHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, MD, USA.
Hulya YalçinHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, MD, USA.
Sanjay SivalokanathanHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, MD, USA.
Gabriela V GreenlandHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, MD, USA.
Nestor VasquezHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, MD, USA.
Fatih YalçinHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, MD, USA.
Min ZhaoDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
Ines ValentaDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
Peter GanzDivision of Cardiology, University of California San Francisco, 555 Mission Bay Blvd South, Smith Cardiovascular Research Building, 452K, San Francisco, CA, 94158, USA.
Miguel Hernandez PampaloniDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Stefan ZimmermanDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
Thomas H SchindlerDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
Theodore P AbrahamHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, MD, USA.
M Roselle AbrahamHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, MD, USA. Roselle.Abraham@ucsf.edu.
Johns Hopkins University · USUniversity of California, San Francisco · USNational Yang Ming Chiao Tung University · TWUniversity of California System · US

Funding

Imaging of the Myocardial Microenvironment to Facilitate Stem Cell EngraftmentR01HL092985 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ABRAHAM, MARIA ROSELLE, WAHL, RICHARD LEO · 2010 to 2014
$2.3M
NHLBI NIH HHS R01 HL092985
6 · The paper itself

Abstract

backgroundVasodilator-induced transient left ventricular cavity dilation (LVCD) by positron emission tomography (PET) is associated with microvascular dysfunction in hypertrophic cardiomyopathy (HCM). Here we assessed whether HCM patients who develop LVCD by PET during vasodilator stress also develop LV cavity dilation by echocardiography (ECHO-LVCD) following exercise stress.

methodsA retrospective analysis of cardiac function and myocardial blood flow (MBF) was conducted in 108 HCM patients who underwent perfusion-PET and exercise-ECHO as part of their clinical evaluation. We performed a head-to-head comparison of LV volumes and ejection fraction (LVEF) at rest and stress (during vasodilator stress, post-exercise), in 108 HCM patients. A ratio > 1.13 of stress to rest LV volumes was used to define PET-LVCD, and a ratio > 1.17 of stress to rest LVESV was used to define ECHO-LVCD. Patients were divided into 2 groups based on the presence/absence of PET-LVCD. MBF and myocardial flow reserve were quantified by PET, and global longitudinal strain (GLS) was assessed by ECHO at rest/stress in the two groups.

resultsPET-LVCD was observed in 51% (n = 55) of HCM patients, but only one patient had evidence of ECHO-LVCD (ratio = 1.36)-this patient also had evidence of PET-LVCD (ratio = 1.20). The PET-LVCD group had lower PET-LVEF during vasodilator stress, but ECHO-LVEF increased in both groups post-exercise. The PET-LVCD group demonstrated higher LV mass, worse GLS at rest/stress, and lower myocardial flow reserve. Incidence of ischemic ST-T changes was higher in the PET-LVCD group during vasodilator stress (42 vs 17%), but similar (30%) in the two groups during exercise.

conclusionPET-LVCD reflects greater degree of myopathy and microvascular dysfunction in HCM. Differences in the cardiac effects of exercise and vasodilators and timing of stress-image acquisition could underlie discordance in ischemic EKG changes and LVCD by ECHO and PET, in HCM.

Indexed as

AdultAgedCardiomyopathy, HypertrophicEchocardiographyExerciseExercise TestFemaleGenotypeHeart VentriclesHumansHypertrophy, Left VentricularIncidenceMaleMicrocirculationMiddle AgedMuscular DiseasesVasodilator AgentsechocardiographyHypertrophic cardiomyopathyleft ventricular cavity dilationpositron emission tomographystrain

Identifiers

PMID30456498
OpenAlexW2900520145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.