ArticleNeuroradiology2019
Associations of hemodynamics, morphology, and patient characteristics with aneurysm rupture stratified by aneurysm location.
Article in Neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machine Learning Algorithms to Predict the Risk of Rupture of Intracranial Aneurysms: a Systematic Review.Clinical neuroradiology · 2025Pooled it
- Endoluminal flow diverters in the treatment of sidewall and bifurcation aneurysm: A systematic review and meta-analysis of complications and angiographic outcomes.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022Pooled it
- Insights into the Mechanisms Underlying the Lower Rupture Risk of Paraclinoid Aneurysms: a Comparative Analysis with Other Aneurysm Locations.Clinical neuroradiology · 2026Article
- Middle Cerebral Artery Bifurcation Geometry and Aneurysm Formation: A Propensity Score-Matched 3D Rotational Morphometry Study.Diagnostics (Basel, Switzerland) · 2026Article
- Intracranial Aneurysm Wall Phenotypes: Clinical, Morphological, and Hemodynamic Influences.Stroke (Hoboken, N.J.) · 2025Article
- Predicting Cerebral Aneurysm Rupture: The Role of Computational Fluid Dynamics.Neuroimaging clinics of North America · 2025Review
- Incidental aneurysm rupture during endovascular thrombectomy for acute ischaemic stroke.BMJ case reports · 2025Article
- Discriminators of Paraclinoid Aneurysm Rupture Based On Morphological Computer-Assisted Semiautomated Measurement (CASAM) and Hemodynamic Analysis.Clinical neuroradiology · 2025Article
- Imaging of Intracranial Aneurysms: A Review of Standard and Advanced Imaging Techniques.Translational stroke research · 2025Review
- The effect of clinical, bifurcation, and aneurysm morphological characteristics on the risk of rupture in internal carotid artery bifurcation aneurysms.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Observational
- Hemodynamic Characteristics in Ruptured and Unruptured Intracranial Aneurysms: A Prospective Cohort Study Utilizing the AneurysmFlow Tool.AJNR. American journal of neuroradiology · 2025Article
- Using machine learning to predict the rupture risk of multiple intracranial aneurysms.Frontiers in neurology · 2025Article
- Rupture risk assessment for AComA aneurysms with morphological, hemodynamic and structural mechanical analysis.PloS one · 2025Article
- Computational fluid dynamics and shape analysis enhance aneurysm rupture risk stratification.International journal of computer assisted radiology and surgery · 2025Article
- Distribution of rupture sites and blebs on intracranial aneurysm walls suggests distinct rupture patterns in ACom and MCA aneurysms.International journal for numerical methods in biomedical engineering · 2024Article
- Article
- Investigation of the morphometric characteristics of internal carotid artery between sexes and in patients with intracranial aneurysms.Surgical and radiologic anatomy : SRA · 2024Article
- Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms.Current medical science · 2024Article
- Unveiling rupture risk and clinical outcomes in midline aneurysms: A matched cohort analysis investigating the impact of localization within the anterior or posterior circulation.Neurosurgical review · 2024Article
- Risk analysis of intracranial aneurysm rupture based on the arterial segment of origin.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThe mechanisms of cerebral aneurysm rupture are not fully understood. We analyzed the associations of hemodynamics, morphology, and patient age and gender with aneurysm rupture stratifying by location.
methodsUsing image-based models, 20 hemodynamic and 17 morphological parameters were compared in 1931 ruptured and unruptured aneurysms with univariate logistic regression. Rupture rates were compared between males and females as well as younger and older patients and bifurcation versus sidewall aneurysms for different aneurysm locations. Subsequently, associations between hemodynamics and morphology and patient as well as aneurysm characteristics were analyzed for aneurysms at five locations.
resultsCompared to unruptured aneurysms, ruptured aneurysms were characterized by a more irregular shape and were exposed to a more adverse hemodynamic environment described by faster flow, higher wall shear stress, more oscillatory shear, and more unstable and complex flows. These associations with rupture status were consistent for different aneurysm locations. Rupture rates were significantly higher in males at the internal carotid artery (ICA) bifurcation, ophthalmic ICA, and the middle cerebral artery (MCA) bifurcation. At the anterior communicating artery (ACOM) and MCA bifurcation, they were significantly higher for younger patients. Bifurcation aneurysms had significantly larger rupture rates at the MCA and posterior communicating artery (PCOM). In these groups with higher rupture rates, aneurysms were characterized by adverse hemodynamics and more complex shapes.
conclusionHemodynamic and morphological differences between ruptured and unruptured aneurysms are consistent across locations. Adverse morphology and hemodynamics are related to rupture as well as younger age, male gender, and bifurcation aneurysms.
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