ArticleLife science alliance2018
Co-existing feedback loops generate tissue-specific circadian rhythms.
Article in Life science alliance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The trial behind it
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Who cites it
32 citing papers in PubMed.
- Time after time - circadian clocks through the lens of oscillator theory.FEBS letters · 2026Review
- Ocular social jetlag: a driver of immune-metabolic dysfunction in dry eye disease.Frontiers in immunology · 2026Review
- CHRONO regulates the circadian clock via the REV-ERBα - BMAL1 loop.Npj biological timing and sleep · 2025Article
- scPrisma infers, filters and enhances topological signals in single-cell data using spectral template matching.Nature biotechnology · 2023Article
- Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock.PLoS genetics · 2023Article
- A Potential Effect of Circadian Rhythm in the Delivery/Therapeutic Performance of Paclitaxel-Dendrimer Nanosystems.Journal of functional biomaterials · 2023Article
- Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock.PLoS biology · 2023Article
- Deconstructing the functional neuroanatomy of the choroid plexus: an ontogenetic perspective for studying neurodevelopmental and neuropsychiatric disorders.Molecular psychiatry · 2022Review
- Data-driven modelling captures dynamics of the circadian clock of Neurospora crassa.PLoS computational biology · 2022Article
- Combined multiple transcriptional repression mechanisms generate ultrasensitivity and oscillations.Interface focus · 2022Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Discovering design principles for biological functionalities:Perspectives from systems biology.Journal of biosciences · 2022Review
- Different levels of circadian (de)synchrony -- where does it hurt?F1000Research · 2022Review
- Mathematical Modeling in Circadian Rhythmicity.Methods in molecular biology (Clifton, N.J.) · 2022Article
- An effective model of endogenous clocks and external stimuli determining circadian rhythms.Scientific reports · 2021Article
- Pathway-level analysis of genome-wide circadian dynamics in diverse tissues in rat and mouse.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Extensive tissue-specific expression variation and novel regulators underlying circadian behavior.Science advances · 2021Article
- Single-cell transcriptomics allows novel insights into aging and circadian processes.Briefings in functional genomics · 2020Review
- The Making and Breaking of RNAs: Dynamics of Rhythmic RNA Expression in Mammals.Journal of biological rhythms · 2020Review
- Seasonality and light phase-resetting in the mammalian circadian rhythm.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene regulatory feedback loops generate autonomous circadian rhythms in mammalian tissues. The well-studied core clock network contains many negative and positive regulations. Multiple feedback loops have been discussed as primary rhythm generators but the design principles of the core clock and differences between tissues are still under debate. Here we use global optimization techniques to fit mathematical models to circadian gene expression profiles for different mammalian tissues. It turns out that for every investigated tissue multiple model parameter sets reproduce the experimental data. We extract for all model versions the most essential feedback loops and find auto-inhibitions of period and cryptochrome genes,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.