ArticleJACC. Basic to translational science2018
Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension.
Article in JACC. Basic to translational science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Non-Invasive Auricular Vagus Nerve Stimulation Decreases Heart Rate Variability Independent of Caloric Load.Psychophysiology · 2025Trial
- Ventricular arrhythmogenesis in pulmonary hypertension: From right ventricular remodeling to clinical implications.Physiological reports · 2026Review
- Autonomic and neural responses to varying transcutaneous cervical electrical stimulation parameters.Bioelectronic medicine · 2026Article
- No significant modulation of pressure pain sensitivity and cardioception after transauricular vagal nerve stimulation.Pain reports · 2026Article
- Triangular Causality Among Pulmonary Hypertension, Sleep Disorders, and Brain Structure at the Genetic Level: A Mendelian Randomization Study Focused on the Lung-Brain Axis.Nature and science of sleep · 2025Article
- Autonomic control of the pulmonary circulation: Implications for pulmonary hypertension.Experimental physiology · 2025Review
- Pulmonary Hypertension: Pharmacological and Non-Pharmacological Therapies.Life (Basel, Switzerland) · 2024Review
- Current Overview of the Biology and Pharmacology in Sugen/Hypoxia-Induced Pulmonary Hypertension in Rats.Journal of aerosol medicine and pulmonary drug delivery · 2024Review
- EnFUSiasm for Healing: Ultrasound Neuromodulation in PAH.Circulation research · 2024Article
- Carotid Baroreceptor Stimulation Improves Pulmonary Arterial Remodeling and Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.JACC. Basic to translational science · 2024Article
- Autonomic nervous modulation: early treatment for pulmonary artery hypertension.ESC heart failure · 2024Review
- Pulmonary Hypertension and Right Ventricle: A Pathophysiological Insight.Clinical Medicine Insights. Cardiology · 2024Review
- Bioelectronic medicine for restoring autonomic balance in autoimmune diseases.Gut microbiota and integrative wellness · 2023Article
- Inhibition of Th17 cells by donepezil ameliorates experimental lung fibrosis and pulmonary hypertension.Theranostics · 2023Article
- Editorial: Cardiovascular neuromodulation: mechanisms and therapies.Frontiers in cardiovascular medicine · 2023Article
- Vagal nerve stimulation preserves right ventricular function in a rat model of right ventricular pressure overload.Pulmonary circulation · 2022Article
- Strategies for precision vagus neuromodulation.Bioelectronic medicine · 2022Review
- Neurohormonal modulation in pulmonary arterial hypertension.The European respiratory journal · 2021Review
- Effects of nasal high flow on sympathovagal balance, sleep, and sleep-related breathing in patients with precapillary pulmonary hypertension.Sleep & breathing = Schlaf & Atmung · 2021Article
- Development and characterization of a chronic implant mouse model for vagus nerve stimulation.eLife · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.