ArticleeNeuro
Inhibitory Projections from the Inferior Colliculus to the Medial Geniculate body Originate from Four Subtypes of GABAergic Cells.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease.bioRxiv : the preprint server for biology · 2026Article
- Timing and Convergence of Ensemble Activity Govern Auditory Thalamocortical Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Activation of the Gamma-Aminobutyric Acid (GABA)ergic Neural Circuit in Salicylate-Induced Tinnitus: the Inferior Colliculus to the Medial Geniculate Body.Clinical and experimental otorhinolaryngology · 2026Article
- Ultrastructural Synaptic Differences in the Central Inferior Colliculus in the 3xTG Mouse Across Three Disease Stages.The Journal of comparative neurology · 2025Article
- Anatomical and neurochemical profiles of GABAergic projection neurons in the mouse inferior colliculus.Brain structure & function · 2025Article
- Age-related differences in GABAergic synapses across the central inferior colliculus in the Fischer Brown Norway rat.Neurobiology of aging · 2025Article
- A midbrain circuit mechanism for noise-induced negative valence coding.Nature communications · 2025Article
- Segregated input to thalamic areas that project differently to core and shell auditory cortical fields.iScience · 2025Article
- Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats.Frontiers in aging neuroscience · 2025Article
- Ototoxicity-related changes in GABA immunolabeling within the rat inferior colliculus.Hearing research · 2024Article
- Identifying neuron types and circuit mechanisms in the auditory midbrain.Hearing research · 2024Review
- Age-related Changes of GAD1 mRNA Expression in the Central Inferior Colliculus.Translational medicine of aging · 2023Article
- Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus.Frontiers in aging neuroscience · 2023Article
- Cholinergic boutons are closely associated with excitatory cells and four subtypes of inhibitory cells in the inferior colliculus.Journal of chemical neuroanatomy · 2021Article
- Subcortical circuits mediate communication between primary sensory cortical areas in mice.Nature communications · 2021Article
- Kv4.2-Positive Domains on Dendrites in the Mouse Medial Geniculate Body Receive Ascending Excitatory and Inhibitory Inputs Preferentially From the Inferior Colliculus.Frontiers in neuroscience · 2021Article
- Perineuronal nets and subtypes of GABAergic cells differentiate auditory and multisensory nuclei in the intercollicular area of the midbrain.The Journal of comparative neurology · 2020Article
- Neuropeptide Y Expression Defines a Novel Class of GABAergic Projection Neuron in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Effect of Hapln4 Link Protein Deficiency on Extracellular Space Diffusion Parameters and Perineuronal Nets in the Auditory System During Aging.Neurochemical research · 2020Article
- The Density of Perineuronal Nets Increases With Age in the Inferior Colliculus in the Fischer Brown Norway Rat.Frontiers in aging neuroscience · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
GABAergic cells constitute 20-40% of the cells that project from the inferior colliculus [(IC) a midbrain auditory hub] to the medial geniculate body [(MG) the main auditory nucleus of the thalamus]. Four subtypes of GABAergic IC cells have been identified based on their association with perineuronal nets (PNs) and dense rings of axosomatic terminals expressing vesicular glutamate transporter 2 (VGLUT2 rings). These subtypes differ in their soma size and distribution within the IC. Based on previous work emphasizing large GABAergic cells as the origin of GABAergic IC-MG projections, we hypothesized that GABAergic IC cells surrounded by PNs and VGLUT2 rings, which tend to have larger somas, were more likely to project to the MG than smaller cells lacking these extracellular markers. Here, we injected retrograde tract tracers into the MG of guinea pigs of either sex and analyzed retrogradely labeled GABAergic cells in the ipsilateral IC for soma size and association with PNs and/or VGLUT2 rings. We found a range of GABAergic soma sizes present within the IC-MG pathway, which were reflective of the full range of GABAergic soma sizes present within the IC. Further, we found that all four subtypes of GABAergic IC cells participate in the IC-MG pathway, and that GABAergic cells lacking PNs and VGLUT2 rings were more prevalent within the pathway than would be expected based on their overall prevalence in the IC. These results may provide an anatomical substrate for the multiple roles of inhibition in the IC-MG pathway, which have emerged in electrophysiological studies.
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