Evidence map›Paper›PMID 30456288›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018

Neuropsychological comparison of incident MCI and prevalent MCI.

Allison Hansen, Richard J Caselli, Gretchen Schlosser-Covell, Michael A Golafshar, Amylou C Dueck, Bryan K Woodruff, Cynthia M Stonnington, Yonas E Geda, Dona E C Locke

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Longitudinal neuropsychological evaluation allows diagnosis of MCI with less severe memory change.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Allison HansenTranslational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, AZ, USA.
Richard J CaselliDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Gretchen Schlosser-CovellDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Michael A GolafsharDivision of Biomedical Statistics and Informatics, Mayo Clinic, Scottsdale, AZ, USA.
Amylou C DueckDivision of Biomedical Statistics and Informatics, Mayo Clinic, Scottsdale, AZ, USA.
Bryan K WoodruffDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Cynthia M StonningtonDepartment of Psychiatry and Psychology, Scottsdale, AZ, USA.
Yonas E GedaDepartment of Psychiatry and Psychology, Scottsdale, AZ, USA.
Dona E C LockeDepartment of Psychiatry and Psychology, Scottsdale, AZ, USA.
Mayo Clinic in Arizona · USScottsdale Community College · US

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
PET, APOE & the Preclinical Course of Alzheimer's DiseaseR01AG031581 · NIA · BANNER ALZHEIMER'S INSTITUTE · PI CASELLI, RICHARD J., REIMAN, ERIC MICHAEL · 2008 to 2018
$16.6M
NIA NIH HHS P30 AG019610NIA NIH HHS R01 AG031581
6 · The paper itself

Abstract

introductionLittle empirical work has been done to examine differences between mild cognitive impairment (MCI) diagnosed in research settings with longitudinal data (incident MCI) and MCI diagnosed in clinical settings (prevalent MCI). Because Alzheimer's disease progresses over a clinicopathological continuum, we examined the cognitive differences between these two different sources of MCI patients.

methodsWe compared 52 consecutively identified patients with prevalent amnestic MCI with 53 incident amnestic MCI participants from the Arizona APOE study. Neuropsychological data from common tests were compared encompassing four cognitive domains and one global indicator.

resultsPrevalent MCI cases performed significantly worse than incident MCI cases on global as well as domain-specific measures. DISCUSSION: By the time patients seek evaluation for memory loss, they have more severe single domain, amnestic MCI than research subjects with incident MCI. Studies of MCI should distinguish incident and prevalent not just single- and multiple-domain MCI.

Indexed as

Alzheimer'sCognitive declineCognitive functioningDementiaIncidenceMild cognitive impairmentPrevalence

Identifiers

PMID30456288
PMCPMC6234916
OpenAlexW2894290264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.