ArticleSAGE open medicine2018
Anti-proliferative and anti-inflammatory activities of the sea cucumber
Article in SAGE open medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Assessment of the therapeutic efficacy of Holothuria polii extract during the muscular phase of Trichinella spiralis infection in albino mice.Scientific reports · 2026Article
- Unveiling the Hidden Biotechnological Potential of the Vermetid Gastropod Vermetus triquetrus: Insights into an Unexplored Marine Resource.Marine biotechnology (New York, N.Y.) · 2026Article
- Marine Species, Metabolites and Macromolecules as Potential Therapeutics Against Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD): A Comprehensive Review.Current topics in medicinal chemistry · 2026Review
- Molecular docking and pharmacokinetics of Roweothuria polii compounds with in vivo anti-Eimeria papillata activity.Veterinary research communications · 2025Article
- Characteristics and bioinformatics of peptides from natural and cultured sandfish (Food chemistry. Molecular sciences · 2025Article
- A potential therapeutic effect of sea cucumberJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Structural Characterization and Profiles of Saponins from Two Algerian Sea Cucumbers.Molecules (Basel, Switzerland) · 2024Article
- How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue.Foods (Basel, Switzerland) · 2023Article
- Antioxidant and Anti-inflammatory Activity of Sea Cucumber (Bioinformatics and biology insights · 2023Article
- Anti-Inflammatory Effects of Compounds from Echinoderms.Marine drugs · 2022Review
- Cancer Cell Inhibiting Sea Cucumber (Nutrients · 2022Article
- Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways.Molecular biology reports · 2020Review
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSea cucumbers are considered among the most important functional foods. Following bioassay guided fractionation, we assessed the anti-proliferative and anti-inflammatory activities of
methodsSea cucumber ethanolic extract and the partially purified aqueous fractions were assessed for their anti-proliferative activities. These latter bioactivities were evaluated in the highly invasive MDA-MB-231 human breast cancer cells in two-dimensional and three-dimensional cultures using trypan blue exclusion assay. The tumor-suppressive effects of sea cucumber ethanolic extract and aqueous fractions were assayed by measuring the trans-well invasion of MDA-MB-231 cells and the expression of some epithelial mesenchymal transition markers using quantitative reverse-transcription polymerase chain reaction and western blot analysis. The anti-inflammatory activity of the aqueous fraction was tested by measuring the secreted levels of interleukin-6, nitric oxide, and matrix metalloproteinase 9 in endotoxin-induced mammary epithelial SCp2 cells and interleukin-1β in phorbol-12-myristate-13-acetate-activated human monocytic THP-1 cells.
resultsSea cucumber ethanolic extract and the aqueous fraction significantly decreased the proliferation of MDA-MB-231 cells by more than 50% at similar and noncytotoxic concentrations and caused an arrest in the S-phase of the cell cycle of treated cells. In contrast, petroleum ether, chloroform, ethyl acetate, and
conclusionThe data reveal for the first time promising anti-proliferative and anti-inflammatory activities in
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