ArticleEvoDevo2018
A two-level model for the role of complex and young genes in the formation of organism complexity and new insights into the relationship between evolution and development.
Article in EvoDevo, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Internalized Evolutionary Inertia on Body Plan Evolution.Evolution & development · 2026Review
- A sub-set of guanine- and cytosine-rich genes are actively transcribed at the nuclear lamin B1 region.Cellular and molecular life sciences : CMLS · 2026Article
- The haplotype-resolved telomere-to-telomere carnation (Horticulture research · 2024Article
- Approaches for the Identification of Intrinsically Disordered Protein Domains.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Gene Expression Profile Provides Novel Insights of Fasting-Refeeding Response in Zebrafish Skeletal Muscle.Nutrients · 2022Article
- Diversity in Expression Biases of Lineage-Specific Genes During Development and Anhydrobiosis Among Tardigrade Species.Evolutionary bioinformatics online · 2022Article
- The Distinct Properties of the Consecutive Disordered Regions Inside or Outside Protein Domains and Their Functional Significance.International journal of molecular sciences · 2021Article
- Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions.Scientific reports · 2021Article
- Conserved paradoxical relationships among the evolutionary, structural and expressional features of KRAB zinc-finger proteins reveal their special functional characteristics.BMC molecular and cell biology · 2021Article
- Gene Size Matters: An Analysis of Gene Length in the Human Genome.Frontiers in genetics · 2021Article
- Adaptation and Conservation throughout the Drosophila melanogaster Life-Cycle.Genome biology and evolution · 2019Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHow genome complexity affects organismal phenotypic complexity is a fundamental question in evolutionary developmental biology. Previous studies proposed various contributing factors of genome complexity and tried to find the connection between genomic complexity and organism complexity. However, a general model to answer this question is lacking. Here, we introduce a 'two-level' model for the realization of genome complexity at phenotypic level.
resultsFive representative species across Protostomia and Deuterostomia were involved in this study. The intrinsic gene properties contributing to genome complexity were classified into two generalized groups: the complexity and age degree of both protein-coding and noncoding genes. We found that young genes tend to be simpler; however, the mid-age genes, rather than the oldest genes, show the highest proportion of high complexity. Complex genes tend to be utilized preferentially in each stage of embryonic development, with maximum representation during the late stage of organogenesis. This trend is mainly attributed to mid-age complex genes. In contrast, young genes tend to be expressed in specific spatiotemporal states. An obvious correlation between the time point of the change in over- and under-representation and the order of gene age was observed, which supports the funnel-like model of the conservation pattern of development. In addition, we found some probable causes for the seemingly contradictory 'funnel-like' or 'hourglass' model.
conclusionsThese results indicate that complex and young genes contribute to organismal complexity at two different levels: Complex genes contribute to the complexity of individual proteomes in certain states, whereas young genes contribute to the diversity of proteomes in different spatiotemporal states. This conclusion is valid across the five species investigated, indicating it is a conserved model across Protostomia and Deuterostomia. The results in this study also support 'funnel-like model' from a new viewpoint and explain why there are different evo-devo relation models.
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