ArticleImmunity & ageing : I & A2018
A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study.
Article in Immunity & ageing : I & A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 55 citations in OpenAlex.
- Decreased Peripheral Naïve T Cell Number and Its Role in Predicting Cardiovascular and Infection Events in Hemodialysis Patients.Frontiers in immunology · 2021Trial
- Monocytes as an Early Predictor for Patients with Acute Paraquat Poisoning: A Retrospective Analysis.BioMed research international · 2019Trial
- Ultra-Processed Foods and Chronic Kidney Disease: Is Inflammaging the Missing Link?Biomolecules · 2026Review
- Adaptive immune cells and kidney function in older adults: sex-specific associations in the health and retirement study (HRS).Frontiers in aging · 2026Article
- Aging-associated immune signature as a predictor of mortality in end-stage renal disease: results from the longitudinal iESRD study.Immunity & ageing : I & A · 2025Article
- Leukocyte Dysregulation and Biochemical Alterations in End-Stage Kidney Disease Patients Under Hemodialysis.Diseases (Basel, Switzerland) · 2025Article
- Variability of the lymphocyte-to-monocyte ratio in patients with chronic kidney disease on hemodialysis.PloS one · 2025Article
- Composition of peripheral blood immune cell compartment in stage 5 chronic kidney disease is affected by smoking and other risk factors associated with systemic inflammatory response.Frontiers in immunology · 2025Article
- Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis.Immunity & ageing : I & A · 2024Article
- Hemodiafiltration May Be Associated with Senescence-Related Phenotypic Alterations of Lymphocytes, Which May Predict Mortality in Patients Undergoing Dialysis.International journal of molecular sciences · 2024Article
- Transplant Candidates of 70+ Years Have Superior Survival If Receiving Pre-Emptively a Living Donor Kidney.Journal of clinical medicine · 2024Article
- Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction.Drugs & aging · 2024Review
- Cutaneous adaptive immunity and uraemia: a narrative review.Frontiers in immunology · 2024Review
- Immunological features of ESRD patients undergoing hemodialysis of various ages.International urology and nephrology · 2024Article
- Review
- Exercise and chronic kidney disease: potential mechanisms underlying the physiological benefits.Nature reviews. Nephrology · 2023Review
- Article
- Decreased Peripheral Blood Lymphocyte Count Predicts Poor Treatment Response in Peritoneal Dialysis-Associated Peritonitis.Journal of inflammation research · 2023Article
- Anti-staphylococcus aureus adaptive immunity is impaired in end-stage renal disease patients on hemodialysis: one-year longitudinal study.Frontiers in immunology · 2023Article
- Epigenetic quantification of immunosenescent CD8Aging cell · 2022Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of the immune system. Nevertheless, the etiology and impact of these changes in ESRD patients remain unknown.
resultsCompared to healthy individuals, ESRD patients exhibit accelerated immunosenescence in both T cell and monocyte compartments, characterized by a dramatic reduction in naïve CD4+ and CD8+ T cell numbers but increase in CD8+ T
conclusionsAging-associated adaptive and innate immune changes are aggravated in ESRD and are associated with cardiovascular diseases. For the first time, our study demonstrates the potential link between immunosenescence in ESRD and duration of exposure to the uremic milieu.
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