ArticleNature methods2018
Cell-type-specific and projection-specific brain-wide reconstruction of single neurons.
Article in Nature methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
- POINTseq: Cell-type-specific barcoding reveals single-cell projection architecture of the mouse dopaminergic system.Neuron · 2026Article
- WTR: A Toolkit for Functional Anterograde Transsynaptic Circuit Mapping.Research square · 2026Article
- Dual adeno-associated virus system for selective and sparse labeling of astrocytes.Neural regeneration research · 2026Article
- A quantitative and precision‑oriented neuronal reconstruction approach based on data grading.Brain informatics · 2026Article
- A Million-Scale, Difficulty-Stratified Optical-Microscopy Image Annotation for Neuron Reconstruction.Scientific data · 2026Article
- AAV-Based Bright and Sparse Labeling of Versatile Neurons Adaptable in Cre-Dependent Genetic Backgrounds.eNeuro · 2026Article
- Linear ubiquitination of the NMDA receptor GluN2A subunit facilitates the GluN2B-to-GluN2A switch and synaptic maturation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Anatomical and neurochemical profiles of GABAergic projection neurons in the mouse inferior colliculus.Brain structure & function · 2025Article
- A detailed protocol for sparse and bright labeling of neurons via dual adeno-associated virus vectors with Cre recombination.Anatomical science international · 2025Article
- Image enhancement network based on fiber topology-preserving multi-module fusion for neuron reconstruction.Biomedical optics express · 2025Article
- The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input.PLoS biology · 2025Article
- A three dimensional immunolabeling method with peroxidase-fused nanobodies and fluorochromized tyramide-glucose oxidase signal amplification.Communications biology · 2025Article
- Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Morphological segmentation with tiling light sheet microscopy to quantitatively analyze the three-dimensional structures of spinal motoneurons.Cell regeneration (London, England) · 2025Article
- Reconstruction of Single-Neuron Projectomes in Mice.Bio-protocol · 2025Article
- Temporal Association Cortex Gates Sound-Evoked Arousal from NREM Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Tunable dual-AAV sparse labeling of PVFrontiers in neural circuits · 2025Article
- Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.Nature communications · 2024Article
- Collaborative augmented reconstruction of 3D neuron morphology in mouse and human brains.Nature methods · 2024Article
- Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We developed a dual-adeno-associated-virus expression system that enables strong and sparse labeling of individual neurons with cell-type and projection specificity. We demonstrated its utility for whole-brain reconstruction of midbrain dopamine neurons and striatum-projecting cortical neurons. We further extended the labeling method for rapid reconstruction in cleared thick brain sections and simultaneous dual-color labeling. This labeling system may facilitate the process of generating mesoscale single-neuron projectomes of mammalian brains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.