Evidence map›Paper›PMID 30455409›Full record

ArticleAging2018

Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in

Christopher J Gaffney, Amelia Pollard, Thomas F Barratt, Dumitru Constantin-Teodosiu, Paul L Greenhaff, Nathaniel J Szewczyk

Open access · greenAbstract read
In one paragraph

Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Synthesis, Anthelmintic Activity, and Mechanism of Action of 5-Aryl-1Journal of agricultural and food chemistry · 2025
    Article
  4. Review
  5. Article
  6. Form and function of actin impacts actin health and aging.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. A novelBiology methods & protocols · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Development of aging research inCurrent research in food science · 2024
    Review
  13. Article
  14. Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treatedProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Increased mitochondrial CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Christopher J GaffneyMRC/ARUK Centre for Musculoskeletal Ageing Research, NIHR Nottingham BRC, University of Nottingham, Nottingham, UK.
Amelia PollardMRC/ARUK Centre for Musculoskeletal Ageing Research, NIHR Nottingham BRC, University of Nottingham, Nottingham, UK.
Thomas F BarrattMRC/ARUK Centre for Musculoskeletal Ageing Research, NIHR Nottingham BRC, University of Nottingham, Nottingham, UK.
Dumitru Constantin-TeodosiuMRC/ARUK Centre for Musculoskeletal Ageing Research, NIHR Nottingham BRC, University of Nottingham, Nottingham, UK.
Paul L GreenhaffMRC/ARUK Centre for Musculoskeletal Ageing Research, NIHR Nottingham BRC, University of Nottingham, Nottingham, UK.
Nathaniel J SzewczykMRC/ARUK Centre for Musculoskeletal Ageing Research, NIHR Nottingham BRC, University of Nottingham, Nottingham, UK.
University of Nottingham · GBNottingham Biomedical Research Centre · GBLancaster University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden.

Indexed as

AgingAdenosine TriphosphateAnimalsCaenorhabditis elegansEnergy MetabolismGene Expression RegulationGreen Fluorescent ProteinsMitochondriaMusclesMyosinsSarcomeresSarcopeniaTemperatureAdenosine TriphosphateGreen Fluorescent ProteinsMyosinsageingATP productionC. elegansmitochondriamusclesarcomeresarcopenia

Identifiers

PMID30455409
PMCPMC6286836
OpenAlexW2900975761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.