ArticleJournal of immunology (Baltimore, Md. : 1950)2018
Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2
Christopher T Johndrow, Michael F Goldberg, Alison J Johnson, Tony W Ng, Shajo Kunnath-Velayudhan, Gregoire Lauvau, Daniel H Kaplan, Graeme H Gossel, Ulrich D Kadolsky, Andrew J Yates and 3 more
Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors at 6 institutions in 3 countries.
Christopher T JohndrowDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Michael F GoldbergDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455.
Alison J JohnsonDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Tony W NgDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0002-2460-7929
Shajo Kunnath-VelayudhanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Gregoire LauvauDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Daniel H KaplanDepartment of Dermatology, University of Pittsburgh, Pittsburgh, PA 15261.
Graeme H GosselDepartment of Physics and Astronomy, Hunter College and the City University of New York, New York, NY 10065.
Ulrich D KadolskyBiomedical Research Centre at Guy's and St. Thomas' National Health Service Foundation Trust and King's College London, London SE1 9RT, United Kingdom.ORCID 0000-0002-7016-1956
Andrew J YatesDepartment of Pathology and Cell Biology, Columbia University, New York, NY 10032.ORCID 0000-0003-4606-4483
John ChanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Steven A PorcelliDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461; steven.porcelli@einstein.yu.edu.ORCID 0000-0002-4441-9888
Albert Einstein College of Medicine · USCity University of New York · USColumbia University · USNational Health Service · GBUniversity of Minnesota · USUniversity of Pittsburgh · US
Funding
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0M
"The Tuberculous Granuloma"P01AI063537 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI CHAN, JOHN R. · 2005 to 2015
$15.7M
MOLECULAR PATHOGENESIS OF INFECTIOUS DISEASEST32AI007506 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2012
$3.7M
Construction of safe and effective live tuberculosis vaccinesR01AI093649 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PORCELLI, STEVEN A · 2011 to 2015
Effective subunit vaccines require the incorporation of adjuvants that stimulate cells of the innate immune system to generate protective adaptive immune responses. Pattern recognition receptor agonists are a growing class of potential adjuvants that can shape the character of the immune response to subunit vaccines by directing the polarization of CD4 T cell differentiation to various functional subsets. In the current study, we applied a high-throughput in vitro screen to assess murine CD4 T cell polarization by a panel of pattern recognition receptor agonists. This identified lipopeptides with TLR2 agonist activity as exceptional Th1-polarizing adjuvants. In vivo, we demonstrated that i.v. administration of TLR2 agonists with Ag in mice replicated the findings from in vitro screening by promoting strong Th1 polarization. In contrast, TLR2 agonists inhibited priming of Th1 responses when administered cutaneously in mice. This route-specific suppression was associated with infiltrating CCR2
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
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