ArticleThe Journal of biological chemistry2019
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026Review
- Construction of Tandem Multimers with Different Combinatorial Forms of BmSPI38 and BmSPI39 and Analysis of Their Expression and Activity inInternational journal of molecular sciences · 2025Article
- Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis.Frontiers in cellular and infection microbiology · 2025Review
- Article
- Amino Acid Substitutions at P1 Position Change the Inhibitory Activity and Specificity of Protease Inhibitors BmSPI38 and BmSPI39 fromMolecules (Basel, Switzerland) · 2023Article
- Fabp5 is a common gene between a high-cholesterol diet and acute pancreatitis.Frontiers in nutrition · 2023Article
- The role of neutrophil elastase in aortic valve calcification.Journal of translational medicine · 2022Article
- Mobilization of CD11bFrontiers in immunology · 2022Article
- Circulating monocytes in acute pancreatitis.Frontiers in immunology · 2022Review
- Betulinic Acid Ameliorates the Severity of Acute Pancreatitis via Inhibition of the NF-κB Signaling Pathway in Mice.International journal of molecular sciences · 2021Article
- Pancreatitis severity in mice with impaired CFTR function but pancreatic sufficiency is mediated via ductal and inflammatory cells-Not acinar cells.Journal of cellular and molecular medicine · 2021Article
- Oral Phenotype and Salivary Microbiome of Individuals With Papillon-Lefèvre Syndrome.Frontiers in cellular and infection microbiology · 2021Article
- The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis.International journal of medical sciences · 2021Review
- Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling.Cancer research · 2020Article
- The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis.Frontiers in cell and developmental biology · 2020Review
- Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute pancreatitis is characterized by premature intracellular protease activation and infiltration of inflammatory cells, mainly neutrophil granulocytes and macrophages, into the organ. The lysosomal proteases cathepsin B, D, and L have been identified as regulators of early zymogen activation and thus modulators of the severity of pancreatitis. Cathepsin C (CTSC, syn. dipeptidly-peptidase I) is a widely expressed, exo-cystein-protease involved in the proteolytic processing of various other lysosomal enzymes. We have studied its role in pancreatitis. We used CTSC-deleted mice and their WT littermates in two experimental models of pancreatitis. The mild model involved eight hourly caerulein injections and the severe model partial duct ligation. Isolated pancreatic acini and spleen-derived leukocytes were used for
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