Evidence map›Paper›PMID 30455347›Full record

ArticleThe Journal of biological chemistry2019

RORγ regulates the NLRP3 inflammasome.

Cyrielle Billon, Meghan H Murray, Amer Avdagic, Thomas P Burris

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  8. Review
  9. Digoxin mitigates diethylnitrosamine-induced acute liver injury in mice via limiting production of inflammatory mediators.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Article
  10. NLRP3 inflammasome: The rising star in cardiovascular diseases.Frontiers in cardiovascular medicine · 2022
    Review
  11. Nuclear Receptors and Clock Components in Cardiovascular Diseases.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Identification of RORγ as a favorable biomarker for colon cancer.The Journal of international medical research · 2021
    Article
  14. Article
  15. Article
  16. Review
  17. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cyrielle BillonCenter for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, Missouri 63110.
Meghan H MurrayDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104.
Amer AvdagicCenter for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, Missouri 63110.
Thomas P BurrisCenter for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, Missouri 63110. Electronic address: burristhomas@wustl.edu.
University of Health Sciences and Pharmacy · USSaint Louis University · US

Funding

Development of ROR ligands for treatment of circadian rhythm disordersR01MH092769 · NIMH · ST. LOUIS COLLEGE OF PHARMACY · PI BURRIS, THOMAS P, WALKER, JOHN K. · 2011 to 2020
$6.1M
NIMH NIH HHS R01 MH092769
6 · The paper itself

Abstract

RAR-related orphan receptor γ (RORγ) is a nuclear receptor that plays an essential role in the development of T helper 17 (T

Indexed as

Immunity, InnateAnimalsGalactosamineInflammasomesInterleukin-1betaLipopolysaccharidesLiver Failure, AcuteMacrophagesMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinNuclear Receptor Subfamily 1, Group F, Member 3Response ElementsSepsisTh17 CellsGalactosamineIL1B protein, mouseInflammasomesInterleukin-1betaLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseNuclear Receptor Subfamily 1, Group F, Member 3Rorc protein, mousedrug discoveryinflammasomeinnate immunityinterleukin 1 (IL-1)liverliver injurymacrophagenuclear receptortranscription factor

Identifiers

PMID30455347
PMCPMC6322869
OpenAlexW2900968222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.