Evidence map›Paper›PMID 30455292›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Loss of protein synthesis quality control in host-restricted organisms.

Sergey V Melnikov, Antonia van den Elzen, David L Stevens, Carson C Thoreen, Dieter Söll

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Mapping the tRNA modification landscape ofFrontiers in microbiology · 2024
    Article
  4. Review
  5. Ancestral archaea expanded the genetic code with pyrrolysine.The Journal of biological chemistry · 2022
    Article
  6. Article
  7. Genetic innovations in animal-microbe symbioses.Nature reviews. Genetics · 2022
    Review
  8. Article
  9. Bacterial translation machinery for deliberate mistranslation of the genetic code.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. Article
  11. Aminoacyl-tRNA synthetases.RNA (New York, N.Y.) · 2020
    Review
  12. Article
  13. Article
  14. Obligate bacterial endosymbionts limit thermal tolerance of insect host species.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sergey V MelnikovDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511.
Antonia van den ElzenDepartment of Cellular and Molecular Physiology, Yale University, New Haven, CT 06520.
David L StevensDepartment of Chemistry, Yale University, New Haven, CT 06511.
Carson C ThoreenDepartment of Cellular and Molecular Physiology, Yale University, New Haven, CT 06520.
Dieter SöllDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511; dieter.soll@yale.edu.ORCID 0000-0002-3077-8986
Yale University · US

Funding

Studies of Transfer RNAR35GM122560 · NIGMS · YALE UNIVERSITY · PI SOLL, DIETER · 2017 to 2022
$5.6M
Translational control of gene expression by the mTOR pathwayR01GM125955 · NIGMS · YALE UNIVERSITY · PI THOREEN, CARSON CORNELL · 2017 to 2021
$1.8M
NIGMS NIH HHS R01 GM125955NIGMS NIH HHS R35 GM122560
6 · The paper itself

Abstract

Intracellular organisms, such as obligate parasites and endosymbionts, typically possess small genomes due to continuous genome decay caused by an environment with alleviated natural selection. Previously, a few species with highly reduced genomes, including the intracellular pathogens

Indexed as

Amino AcidsAmino Acid SequenceBacteriaConserved SequenceGene Expression Regulation, BacterialProtein BiosynthesisProtein DomainsRNA EditingAmino Acidsaminoacyl-tRNA synthetasesgenome decaymistranslationMuller’s ratchetquality control

Identifiers

PMID30455292
PMCPMC6298100
OpenAlexW2901746378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.