Evidence map›Paper›PMID 30455268›Full record

ArticleThe Journal of experimental medicine2018

Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells.

Inga Sandrock, Annika Reinhardt, Sarina Ravens, Christoph Binz, Anneke Wilharm, Joana Martins, Linda Oberdörfer, Likai Tan, Stefan Lienenklaus, Baojun Zhang and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.

  1. γδ T cells in oral diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Pooled it
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  8. Tick Extracellular Vesicles Alter Epidermal Keratinocyte Function.The Journal of investigative dermatology · 2026
    Article
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  11. Secondary Necrosis Following Caspase-Activation can Occur Independently of Gasdermin E.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  12. Article
  13. HEB collaborates with TCR signaling to upregulatebioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. γδ T cells in immune-mediated kidney disease.European journal of immunology · 2024
    Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Inga SandrockInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Annika ReinhardtInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Sarina RavensInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Christoph BinzInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Anneke WilharmInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Joana MartinsInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Linda OberdörferInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Likai TanInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Stefan LienenklausInstitute of Immunology, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-4790-3445
Baojun ZhangDepartment of Immunology, Duke University Medical Center, Durham, NC.
Ronald NaumannMax-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Yuan ZhuangDepartment of Immunology, Duke University Medical Center, Durham, NC.
Andreas KruegerInstitute of Immunology, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-7873-7334
Reinhold FörsterInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Immo PrinzInstitute of Immunology, Hannover Medical School, Hannover, Germany prinz.immo@mh-hannover.de.ORCID 0000-0002-8789-9578
Medizinische Hochschule Hannover · DEDuke Medical Center · USMax Planck Institute of Molecular Cell Biology and Genetics · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γδ T cells are highly conserved in jawed vertebrates, suggesting an essential role in the immune system. However, γδ T cell-deficient

Indexed as

Models, GeneticModels, ImmunologicalReceptors, Antigen, T-Cell, gamma-deltaAnimalsInterferon-gammaMiceMice, KnockoutSkinTh17 CellsIFNG protein, mouseInterferon-gammaReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID30455268
PMCPMC6279411
OpenAlexW2900639296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.