Evidence map›Paper›PMID 30455235›Full record

ArticleAntimicrobial agents and chemotherapy2019

Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort.

George R Thompson, Charles R Krois, Verena K Affolter, Angela D Everett, E Katarina Varjonen, Victoria R Sharon, Anil Singapuri, Michael Dennis, Ian McHardy, Hong Sik Yoo and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

George R ThompsonDepartment of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA grthompson@ucdavis.edu.
Charles R KroisDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
Verena K AffolterDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Angela D EverettDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
E Katarina VarjonenDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Victoria R SharonDepartment of Dermatology, Zucker School of Medicine at Hofstra Northwell, Hempstead, New York, USA.
Anil SingapuriDepartment of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA.
Michael DennisDepartment of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA.
Ian McHardyDepartment of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA.ORCID 0000-0002-2121-5460
Hong Sik YooDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
Dawn M FedorDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
Nathan P WiederholdDepartment of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA.ORCID 0000-0002-2225-5122
Phylicia A AaronDepartment of Pharmacology, University of California, Davis, Davis, California, USA.
Angie GelliDepartment of Pharmacology, University of California, Davis, Davis, California, USA.ORCID 0000-0003-3351-0683
Joseph L NapoliDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California, USA.
Stephen D WhiteDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
University of California, Davis · USUniversity of California, Berkeley · USHofstra University · USThe University of Texas Health Science Center at San Antonio · USUniversity of California Davis Medical Center · US

Funding

Rdh10 and retinoic acid effects on differentiationR01DK112754 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI NAPOLI, JOSEPH L · 2017 to 2021
$1.9M
Retinoid HomeostasisR01DK102014 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI NAPOLI, JOSEPH L · 2015 to 2019
$1.7M
NIDDK NIH HHS R01 DK102014NIDDK NIH HHS R01 DK112754
6 · The paper itself

Abstract

Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found to be causal. Human patients with alopecia attributed to fluconazole also underwent detailed assessment and in both our murine model and human cohort fluconazole induced telogen effluvium. Future work further examining the mechanism of fluconazole-induced alopecia should be undertaken.

Indexed as

Alopecia AreataAnimalsAntifungal AgentsDisease Models, AnimalFluconazoleHumansMaleMiceRatsRats, WistarTretinoinAntifungal AgentsFluconazoleTretinoinalopeciaantifungalfluconazoleside effect

Identifiers

PMID30455235
PMCPMC6355562
OpenAlexW2901580671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.