Evidence map›Paper›PMID 30455064›Full record

ReviewHearing research2019

Neural crest contributions to the ear: Implications for congenital hearing disorders.

K Elaine Ritter, Donna M Martin

Open access · greenAbstract readReview
In one paragraph

Review in Hearing research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 57 citations in OpenAlex.

  1. Identification of novel genes regulating the development of the palate.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  2. Article
  3. [Incomplete penetrance of SOX10 gene mutation in a family with Waardenburg syndrome type Ⅳ].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Congenital melanocytic nevi in Bardet-Biedl syndrome.Orphanet journal of rare diseases · 2025
    Article
  8. Article
  9. A novelTranslational pediatrics · 2025
    Article
  10. Article
  11. Frontiers in cell and developmental biology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Modern In Vitro Techniques for Modeling Hearing Loss.Bioengineering (Basel, Switzerland) · 2024
    Review
  16. Cochleovestibular Phenotype in a Rare Genetic MED13L Mutation.The journal of international advanced otology · 2024
    Article
  17. Endothelin signaling in development.Development (Cambridge, England) · 2023
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

K Elaine RitterDepartment of Pediatrics, The University of Michigan Medical School, Ann Arbor, MI, USA.
Donna M MartinDepartment of Pediatrics, The University of Michigan Medical School, Ann Arbor, MI, USA; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: donnamm@umich.edu.
University of Michigan · US

Funding

Sensory Mechanisms and Disorders - Administrative SupplementT32DC000011 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michael Thomas Roberts · 1989 to 2026
$9.5M
Developmental Mechanisms of the Chromodomain Gene Chd7R01DC009410 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTIN, DONNA M. · 2009 to 2018
$3.7M
Exploration of Connexin26 Genotypes, Phenotypes, and Gene ReplacementR01DC014456 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTIN, DONNA M., RAPHAEL, YEHOASH · 2016 to 2020
$2.5M
NIDCD NIH HHS R01 DC009410NIDCD NIH HHS R01 DC014456NIDCD NIH HHS T32 DC000011
6 · The paper itself

Abstract

Congenital hearing disorders affect millions of children worldwide and can significantly impact acquisition of speech and language. Efforts to identify the developmental genetic etiologies of conductive and sensorineural hearing losses have revealed critical roles for cranial neural crest cells (NCCs) in ear development. Cranial NCCs contribute to all portions of the ear, and defects in neural crest development can lead to neurocristopathies associated with profound hearing loss. The molecular mechanisms governing the development of neural crest derivatives within the ear are partially understood, but many questions remain. In this review, we describe recent advancements in determining neural crest contributions to the ear, how they inform our understanding of neurocristopathies, and highlight new avenues for further research using bioinformatic approaches.

Indexed as

AnimalsChildEar, ExternalEar, InnerEar, MiddleGene Expression Regulation, DevelopmentalHearing DisordersHumansMolecular BiologyMutationNeural CrestNeurogenesisCochleovestibular ganglionDevelopmentMelanocytesNeurocristopathySchwann cellsStria vascularis

Identifiers

PMID30455064
PMCPMC6456423
OpenAlexW2901209615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.