ArticleJournal of biomechanics2019
Activities of daily living influence tibial cartilage T1rho relaxation times.
Article in Journal of biomechanics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A New Stress Test for Knee Joint Cartilage.Scientific reports · 2019Trial
- The application of transfer learning to T1ρ MRI tibiofemoral cartilage segmentation.Journal of biomechanics · 2026Article
- Relationship between Changes in Physical Activity and Knee Health 18 Months after ACL Reconstruction.Medicine and science in sports and exercise · 2025Article
- CORR Insights®: Does Valgus Bracing Reduce Estimates of Medial Tibial, Medial Femoral, and Patella Cartilage Contact Pressure in Varus Malaligned Medial Knee Osteoarthritis?Clinical orthopaedics and related research · 2025Article
- Walking recovers cartilage compressive strain in vivo.Osteoarthritis and cartilage open · 2024Article
- Influence of running on femoroacetabular joint bone-to-bone distances.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Reproducibility of TOsteoarthritis and cartilage · 2023Article
- Obesity impacts the mechanical response and biochemical composition of patellofemoral cartilage: An in vivo, MRI-based investigation.Journal of biomechanics · 2022Article
- Knee joint unloading and daily physical activity associate with cartilage T2 relaxation times 1 month after ACL injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping.Journal of biomechanics · 2021Article
- Review
- Effect of walking on in vivo tibiofemoral cartilage strain in ACL-deficient versus intact knees.Journal of biomechanics · 2021Article
- The Characteristic Recovery Time as a Novel, Noninvasive Metric for Assessing In Vivo Cartilage Mechanical Function.Annals of biomedical engineering · 2020Article
- Dose and Recovery Response of Patellofemoral Cartilage Deformations to Running.Orthopaedic journal of sports medicine · 2020Article
- Quantifying the biochemical state of knee cartilage in response to running using T1rho magnetic resonance imaging.Scientific reports · 2020Article
- Magnetic resonance imaging (MRI) studies of knee joint under mechanical loading: Review.Magnetic resonance imaging · 2020Review
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Authors and funding
8 authors.
Funding
Abstract
Quantitative T1rho magnetic resonance imaging (MRI) can potentially help identify early-stage osteoarthritis (OA) by non-invasively assessing proteoglycan concentration in articular cartilage. T1rho relaxation times are negatively correlated with proteoglycan concentration. Cartilage compresses in response to load, resulting in water exudation, a relative increase in proteoglycan concentration, and a decrease in the corresponding T1rho relaxation times. To date, there is limited information on changes in cartilage composition resulting from daily activity. Therefore, the objective of this study was to quantify changes in tibial cartilage T1rho relaxation times in healthy human subjects following activities of daily living. It was hypothesized that water exudation throughout the day would lead to decreased T1rho relaxation times. Subjects underwent MR imaging in the morning and afternoon on the same day and were free to go about their normal activities between scans. Our findings confirmed the hypothesis that tibial cartilage T1rho relaxation times significantly decreased (by 7%) over the course of the day with loading, which is indicative of a relative increase in proteoglycan concentration. Additionally, baseline T1rho values varied with position within the cartilage, supporting a need for site-specific measurements of T1rho relaxation times. Understanding how loading alters the proteoglycan concentration in healthy cartilage may hold clinical significance pertaining to cartilage homeostasis and potentially help to elucidate a mechanism for OA development. These results also indicate that future studies using T1rho relaxation times as an indicator of cartilage health should control the loading history prior to image acquisition to ensure the appropriate interpretation of the data.
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