ArticleBiophysical journal2018
Tissue Flow Induces Cell Shape Changes During Organogenesis.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A Predictive Model for Coupling Cell Division Orientation to Tissue Mechanics During Epithelial Morphogenesis.bioRxiv : the preprint server for biology · 2026Article
- A predictive model for coupling cell division orientation to tissue mechanics during epithelial morphogenesis.Frontiers in cell and developmental biology · 2026Article
- Cell Contractile Force-Mediated Morphogenetic Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025Article
- Mechanical control of cell fate decisions in the skin epidermis.Nature communications · 2025Article
- Dynamic forces drive cell and organ morphology changes during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Viscous shear is a key force in Drosophila ventral furrow morphogenesis.Development (Cambridge, England) · 2024Article
- An emerging role for tissue plasticity in developmental precision.Biochemical Society transactions · 2024Review
- From cells to form: A roadmap to study shape emergence in vivo.Biophysical journal · 2023Review
- Understanding laterality disorders and the left-right organizer: Insights from zebrafish.Frontiers in cell and developmental biology · 2022Review
- 3D viscoelastic drag forces contribute to cell shape changes during organogenesis in the zebrafish embryo.Cells & development · 2021Article
- Configurational fingerprints of multicellular living systems.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In embryonic development, cell shape changes are essential for building functional organs, but in many cases, the mechanisms that precisely regulate these changes remain unknown. We propose that fluid-like drag forces generated by the motion of an organ through surrounding tissue could generate changes to its structure that are important for its function. To test this hypothesis, we study the zebrafish left-right organizer, Kupffer's vesicle (KV), using experiments and mathematical modeling. During development, monociliated cells that comprise KV undergo region-specific shape changes along the anterior-posterior axis that are critical for KV function: anterior cells become long and thin, whereas posterior cells become short and squat. Here, we develop a mathematical vertex-like model for cell shapes that incorporates both tissue rheology and cell motility and constrain the model parameters using previously published rheological data for the zebrafish tailbud as well as our own measurements of the KV speed. We find that drag forces due to dynamics of cells surrounding KV could be sufficient or work in concert with previously identified mechanisms to drive KV cell shape changes during KV development. More broadly, these results suggest that cell shape changes during embryonic development and beyond could be driven by dynamic forces not typically considered in models or experiments.
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Registered trials
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