Evidence map›Paper›PMID 30454905›Full record

ReviewPlacenta2019

Fetal membrane architecture, aging and inflammation in pregnancy and parturition.

Ramkumar Menon, Lauren S Richardson, Martha Lappas

Abstract readReview
In one paragraph

Review in Placenta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 2 syntheses or guidelines pooled it, 176 citations in OpenAlex.

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  18. Exposure to Extreme Heat Increases Preterm Birth Risk: Hypothetical Pathophysiological Mechanisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
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  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ramkumar MenonDivision of Maternal-Fetal Medicine & Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA. Electronic address: ram.menon@utmb.edu.
Lauren S RichardsonDivision of Maternal-Fetal Medicine & Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Martha LappasObstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia. Electronic address: mlappas@unimelb.edu.au.
The University of Texas Medical Branch at Galveston · USUniversity of Melbourne · AU

Funding

Fetal Cell Senescence Signals Initiation of ParturitionR01HD084532 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MENON, RAMKUMAR · 2016 to 2020
$695k
Static state of epithelial mesenchymal transition in fetal membrane cells: a novel inflammatory pathway to parturitionR03HD098469 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MENON, RAMKUMAR · 2019 to 2020
$158k
NICHD NIH HHS R01 HD084532NICHD NIH HHS R03 HD098469
6 · The paper itself

Abstract

Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of preterm premature rupture of the fetal membranes (pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as well as the mechanisms of membrane rupture are essential if we are to develop effective treatment strategies to prevent pPROM. In this review, we focus on the role of inflammation and senescence in fetal membrane biology.

Indexed as

Cellular SenescenceInflammationTerm BirthExtraembryonic MembranesFemaleHumansPregnancyPremature BirthFetal membranesInflammationSenescenceStructure

Identifiers

PMID30454905
PMCPMC7041999
OpenAlexW2899545413

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.