Evidence map›Paper›PMID 30454790›Full record

Observational studyThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2018

Cognitive Improvement in Older Adults in the Year After Hip Fracture: Implications for Brain Resilience in Advanced Aging.

Hanadi Ajam Oughli, Gengsheng Chen, J Philip Miller, Ginger Nicol, Meryl A Butters, Michael Avidan, Susan Stark, Eric J Lenze

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04626934 (Can Specific Cognitive Intervention With Post-Acute Cognitively Impaired Hip Fracture Patients Improve Rehabilitation Outcome), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04626934 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Can Specific Cognitive Intervention With Post-Acute Cognitively Impaired Hip Fracture Patients Improve Rehabilitation Outcome

TypeinterventionalSponsorRabin Medical CenterRan2020 to 2024Enrolled80ConditionsHip Fracture, Rehabilitation, Cognitive InterventionArmsspecific cognitive intervention, conventional occupational therapy treatment
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Association Between Prehip Fracture Antidepressant Use and Posthip Fracture Length of Hospital Stay in Medicare Beneficiaries and Assessing Sex Differences.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025
    Article
  9. Prognostic Factors of Hip Fracture in Elderly: A Systematic Review.International journal of preventive medicine · 2024
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Hanadi Ajam OughliDepartment of Psychiatry, Washington University School of Medicine. Electronic address: ajamoughli@wustl.edu.
Gengsheng Chenthe Department of Radiology, Washington University School of Medicine.
J Philip Millerthe Division of Biostatistics, Washington University School of Medicine.
Ginger NicolDepartment of Psychiatry, Washington University School of Medicine.
Meryl A Buttersthe University of Pittsburgh School of Medicine.
Michael Avidanthe Department of Anesthesiology, Washington University School of Medicine.
Susan StarkProgram in Occupational Therapy, Washington University School of Medicine.
Eric J LenzeDepartment of Psychiatry, Washington University School of Medicine.

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Risk Genes for Late-Life Depression after Hip FractureR01MH074596 · NIMH · WASHINGTON UNIVERSITY · PI LENZE, ERIC J · 2007 to 2011
$1.9M
NCATS NIH HHS UL1 TR000448NIMH NIH HHS R01 MH074596
6 · The paper itself

Abstract

objectiveWe examined cognitive function in nondemented, nondelirious older adults 1 year post hip fracture.

designProspective observational study. SETTING AND

participantsThree hundred eighty-six hip fracture patients aged 60 years and older with no history of cognitive impairment, such as clinical dementia or persistent delirium, recruited from eight area hospitals 2-3 days after hip surgery (week 0), and 101 older adults with no recent acute medical events for control comparison.

methodsCognitive function was examined with the Repeatable Battery for the Assessment of Neuropsychological Status and the Short Blessed Test (SBT) at weeks 0 (SBT only), 4, and 52 using a repeated measures mixed model analysis. Baseline predictor variables included demographics, personality, genetic factors, and depressive symptom level.

resultsHip fracture participants had lower cognitive scores than healthy comparisons. Cognitive scores improved in the hip fracture group relative to healthy comparison participants from week 4-52. The only significant predictor of cognitive improvement after hip fracture was education: individuals with college education showed cognitive improvement by week 52, while those with high school or less did not.

conclusionNondemented, nondelirious older adults suffering hip fracture have poorer cognitive function immediately after the fracture but then exhibit cognitive improvement over the ensuing year, especially among those with high education. This demonstrates brain resilience in older adults even in the context of advanced age, medical illness, and frailty.

Indexed as

Adaptation, PhysiologicalCognitionAgedBrainCase-Control StudiesFemaleHip FracturesHumansMaleMiddle AgedNeuropsychological TestsProspective Studiescognitive declinedeliriumHip fracture

Identifiers

PMID30454790
PMCPMC6251311

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.