ArticleeLife2018
Host genetic selection for cold tolerance shapes microbiome composition and modulates its response to temperature.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Experimental temperatures shape host microbiome diversity and composition.Global change biology · 2023Pooled it
- A systematic review of advances in intestinal microflora of fish.Fish physiology and biochemistry · 2021Pooled it
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- Gut microbiota as key mediators of animal acclimation to temperature changes: mechanisms and interventions.Applied and environmental microbiology · 2026Review
- Lighting the way: how the squid-Vibrio model can inform thermal impacts on symbiotic dynamics.The Journal of experimental biology · 2026Review
- Soil microbiome prediction using traditional machine learning and deep learning models.Scientific reports · 2026Article
- Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms.FEMS microbiology reviews · 2026Review
- The Immune-Antioxidant Trade-Off Mediated by Actinobacteria Drives Niche Differentiation: Physiological and Gut Microbiota Responses of Two Cold-Adapted Brown Frog Species to Contrasting Peak Daily Habitat Temperatures.Animals : an open access journal from MDPI · 2025Article
- Effects of Chronic Thermal Stress on the Physiology, Metabolism, Histology, and Gut Microbiota of JuvenileAnimals : an open access journal from MDPI · 2025Article
- Differential Microbial Composition and Fiber Degradation in Two Sloth Species (Bradypus variegatus and Choloepus hoffmanni).Current microbiology · 2025Article
- Alterations and resilience of intestinal microbiota to increased water temperature are accompanied by the recovery of immune function in Nile tilapia.Scientific reports · 2025Article
- Review
- Selection for stress tolerance and longevity in Drosophila melanogaster have strong impacts on microbiome profiles.Scientific reports · 2024Article
- Parabacteroides distasonis regulates the infectivity and pathogenicity of SVCV at different water temperatures.Microbiome · 2024Article
- Resistance to freezing conditions of endemic Antarctic polychaetes is enhanced by cryoprotective proteins produced by their microbiome.Science advances · 2024Article
- Do fish gut microbiotas vary across spatial scales? A case study of Diplodus vulgaris in the Mediterranean Sea.Animal microbiome · 2024Article
- Metabolic and microbial changes in light-vented bulbul during recent northward range expansion.Current zoology · 2024Article
- Early-Life Fecal Transplantation from High Muscle Yield Rainbow Trout to Low Muscle Yield Recipients Accelerates Somatic Growth through Respiratory and Mitochondrial Efficiency Modulation.Microorganisms · 2024Article
- Fish gut microbiome and its application in aquaculture and biological conservation.Frontiers in microbiology · 2024Review
- Extreme drought shapes the gut microbiota composition and function of common cranes (Frontiers in microbiology · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The hologenome concept proposes that microbes and their host organism are an independent unit of selection. Motivated by this concept, we hypothesized that thermal acclimation in poikilothermic organisms, owing to their inability to maintain their body temperature, is connected to their microbiome composition. To test this hypothesis, we used a unique experimental setup with a transgenerational selective breeding scheme for cold tolerance in tropical tilapias. We tested the effects of the selection on the gut microbiome and on host transcriptomic response. Interestingly, we found that host genetic selection for thermal tolerance shapes the microbiome composition and its response to cold. The microbiomes of cold-resistant fish showed higher resilience to temperature changes, indicating that the microbiome is shaped by its host's selection. These findings are consistent with the hologenome concept and highlight the connection between the host and its microbiome's response to the environment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.