Evidence map›Paper›PMID 30454069›Full record

ReviewGenome biology2018

Ten things you should know about transposable elements.

Guillaume Bourque, Kathleen H Burns, Mary Gehring, Vera Gorbunova, Andrei Seluanov, Molly Hammell, Michaël Imbeault, Zsuzsanna Izsvák, Henry L Levin, Todd S Macfarlan and 2 more

Abstract readReview
In one paragraph

Review in Genome biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 801 papers.

0numbers the graph read from it
0cells of the map it votes in
801citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

801 citing papers in PubMed.

  1. Progresses of transposon research inSynthetic and systems biotechnology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Technologies for engineering repetitive DNA.Quantitative biology (Beijing, China) · 2026
    Review
  17. Review
  18. Article
  19. A single species, different repeatomes? Genomic plasticity in Passiflora foetida L. complex and comparative insights across the subgenus Passiflora.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
    Article
  20. Review

741 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guillaume BourqueDepartment of Human Genetics, McGill University, Montréal, Québec, H3A 0G1, Canada. guil.bourque@mcgill.ca.ORCID 0000-0002-3933-9656
Kathleen H BurnsDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Mary GehringWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.
Vera GorbunovaDepartment of Biology, University of Rochester, Rochester, NY, 14627, USA.
Andrei SeluanovDepartment of Biology, University of Rochester, Rochester, NY, 14627, USA.
Molly HammellCold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.
Michaël ImbeaultDepartment of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK.
Zsuzsanna IzsvákMax Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125, Berlin, Germany.
Henry L LevinThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland, USA.
Todd S MacfarlanThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland, USA.
Dixie L MagerTerry Fox Laboratory, British Columbia Cancer Agency and Department of Medical Genetics, University of BC, Vancouver, BC, V5Z1L3, Canada.
Cédric FeschotteDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, 14850, USA. cf458@cornell.edu.

Funding

The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2014 to 2026
$36.9M
Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4M
Regulation And Function Of RetroelementsZIAHD001009 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LEVIN, HENRY L. · 2009 to 2025
$21.8M
Mechanisms of Mammalian Epigenome ReprogrammingZIAHD008933 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MACFARLAN, TODD SCOTT · 2013 to 2025
$19.1M
POPULATION GENETICS OF MOBILE ELEMENTSR01GM059290 · NIGMS · UNIVERSITY OF UTAH · PI BATZER, MARK A, FESCHOTTE, CEDRIC · 1999 to 2018
$8.5M
The role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2M
Genomic and Physiological Impact of Transposable Elements.R35GM122550 · NIGMS · CORNELL UNIVERSITY · PI Cedric Feschotte · 2017 to 2026
$4.4M
Regulation of genome stability by SITR6R01AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI SELUANOV, ANDREI · 2014 to 2018
$1.9M
Transposon Insertion Polymorphisms in Predispositions to Hematopoietic NeoplasiaR01CA163705 · NCI · JOHNS HOPKINS UNIVERSITY · PI BURNS, KATHLEEN H · 2013 to 2017
$1.7M
Human DNA transposons: evolutionary history and genomic impactR01GM077582 · NIGMS · UNIVERSITY OF UTAH · PI FESCHOTTE, CEDRIC · 2007 to 2015
$1.4M
Exonizaton of Alu Insertion PolymorphismsR01GM124531 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BURNS, KATHLEEN H, FLOREA, LILIANA D · 2017 to 2020
$1.3M
Endogenous Retroviruses Co-Opted for Immune DefensesR01GM112972 · NIGMS · UNIVERSITY OF UTAH · PI FESCHOTTE, CEDRIC · 2015 to 2017
$804k
European Research Council 294742NCI NIH HHS R01 CA163705NIA NIH HHS P01 AG047200NIA NIH HHS P01 AG051449NIA NIH HHS R01 AG027237NIA NIH HHS R01 AG046320NIGMS NIH HHS R01 GM059290NIGMS NIH HHS R01 GM077582NIGMS NIH HHS R01 GM112972NIGMS NIH HHS R01 GM124531NIGMS NIH HHS R35 GM122550Wellcome Trust 206688/Z/17/Z
6 · The paper itself

Abstract

Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.

Indexed as

DNA Transposable ElementsAnimalsGene RearrangementHumansMutationPolymorphism, GeneticDNA Transposable Elements

Identifiers

PMID30454069
PMCPMC6240941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.