ArticleItalian journal of pediatrics2018
Differentiating Kawasaki disease from urinary tract infection in febrile children with pyuria and C-reactive protein elevation.
Article in Italian journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Under-Recognized Macrophage Activation Syndrome in Refractory Kawasaki Disease: A Wolf in Sheep's Clothing.Children (Basel, Switzerland) · 2022Article
- Clinical Manifestations and Laboratory Findings of Kawasaki Disease: Beyond the Classic Diagnostic Features.Medicina (Kaunas, Lithuania) · 2022Review
- Can AI Help Pediatricians? Diagnosing Kawasaki Disease Using DRSA.Children (Basel, Switzerland) · 2021Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundKawasaki disease (KD) is sometimes confused with urinary tract infection (UTI) because both can present with pyuria and C-reactive protein (CRP) elevation. The present study investigated the clinical and laboratory findings that can differentiate KD from UTI in febrile children with pyuria and CRP elevation.
methodsMedical records were retrospectively reviewed for children with KD and those with UTI. The clinical and laboratory findings between the KD with pyuria group (n = 48) and the UTI group (n = 118) were compared.
resultsThe KD with pyuria group had older age (P < 0.001) and longer duration of fever (P < 0.001) than the UTI group. In blood tests, both groups showed increased CRP level, but the value of CRP was higher in the KD with pyuria group than in the UTI group (P < 0.001). The KD with pyuria group also showed higher values for liver enzymes than the UTI group (P < 0.001); > 70.0% of children in the KD with pyuria group, but < 20.0% of children in the UTI group possessed elevated liver enzymes (P < 0.001). On urinalysis, 40.7% of the UTI group had a positive nitrite test, but 0.0% of the KD with pyuria group had a positive nitrite test (P < 0.001).
conclusionsElevated liver enzymes are more specific to KD than to UTI, whereas a positive nitrite test is more specific to UTI than to KD. Our findings can be used as diagnostic clues to differentiate KD from UTI in febrile children with pyuria and CRP elevation.
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