Evidence map›Paper›PMID 30454050›Full record

ArticleRespiratory research2018

Heterogeneous burden of lung disease in smokers with borderline airflow obstruction.

Cheryl S Pirozzi, Tian Gu, Pedro M Quibrera, Elizabeth E Carretta, MeiLan K Han, Susan Murray, Christopher B Cooper, Donald P Tashkin, Eric C Kleerup, Igor Barjaktarevic and 11 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Ratio of FEVChest · 2021
    Observational
  3. GPs should not try to detect mild COPD.NPJ primary care respiratory medicine · 2020
    Article
  4. Article
  5. COPD beyond proximal bronchial obstruction: phenotyping and related tools at the bedside.European respiratory review : an official journal of the European Respiratory Society · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 1 country.

Cheryl S PirozziDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, 26 N 1900 E, Salt Lake City, UT, 84132, USA. Cheryl.pirozzi@hsc.utah.edu.ORCID http://orcid.org/0000-0002-1533-1916
Tian GuDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Pedro M QuibreraDepartment of Biostatistics, Collaborative Studies Coordinating Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Elizabeth E CarrettaDepartment of Biostatistics, Collaborative Studies Coordinating Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
MeiLan K HanDepartment of Internal Medicine, University of Michigan, Ann, MI, USA.
Susan MurrayDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Christopher B CooperDepartment of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Donald P TashkinDepartment of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Eric C KleerupDepartment of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Igor BarjaktarevicDepartment of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Eric A HoffmanDepartment of Radiology, University of Iowa, Iowa City, IA, USA.
Carlos H MartinezDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Stephanie A ChristensonDepartment of Medicine, University of California, San Francisco, CA, USA.
Nadia N HanselDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
R Graham BarrDepartment of Medicine, Columbia University, New York, NY, USA.
Eugene R BleeckerDepartment of Medicine, University of Arizona, Tucson, AZ, USA.
Victor E OrtegaDepartment of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Fernando J MartinezDepartment of Medicine, Weill Cornell Medical College, New York, NY, USA.
Richard E KannerDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, 26 N 1900 E, Salt Lake City, UT, 84132, USA.
Robert PaineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, 26 N 1900 E, Salt Lake City, UT, 84132, USA.
NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS)
University of California, Los Angeles · USUniversity of Utah · USUniversity of North Carolina at Chapel Hill · USCornell University · USJohns Hopkins University · USUniversity of Arizona · USUniversity of Iowa · USUniversity of California, San Francisco · USUniversity of Michigan · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI PATRICK T O'SHAUGHNESSY · 1990 to 2026
$40.5M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
Parametric Response Mapping in COPDR01HL122438 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, MARTINEZ, FERNANDO J · 2014 to 2017
$4.0M
Redefining Therapy In Early COPD: RETHINCU01HL128952 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, WOODRUFF, PRESCOTT G · 2015 to 2020
$1.6M
Defining Pathways in COPD Patient Oriented ResearchK24HL138188 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MeiLan K Han · 2017 to 2026
$1.2M
Mentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2M
Hypercoagulability and Chronic Lung Disease in Older AdultsK23HL130627 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OELSNER, ELIZABETH · 2016 to 2019
$686k
NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C HHSN268200900019C, HHSN268200900020CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K23 HL130627NHLBI NIH HHS K24 HL137013NHLBI NIH HHS K24 HL138188NHLBI NIH HHS R01 HL122438NHLBI NIH HHS U01 HL128952NHLBI NIH HHS U01 HL137880NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P30 ES006694NIH HHS K24 HL138188NIH HHS R01 HL122438
6 · The paper itself

Abstract

backgroundThe identification of smoking-related lung disease in current and former smokers with normal FEV

methodsWe compared spirometry, chest CT characteristics, and symptoms between 161 ever-smokers in the discordant group and 940 ever-smokers and 190 never-smokers with normal FEV

resultsThe discordant group had more CT defined emphysema and non-emphysematous gas trapping, lower post-bronchodilator FEV

conclusionsEver-smokers with normal FEV

Indexed as

Cost of IllnessSmokersAgedCohort StudiesFemaleForced Expiratory VolumeHumansLung DiseasesMaleMiddle AgedProspective StudiesPulmonary Disease, Chronic ObstructivePulmonary EmphysemaSpirometryVital CapacityAirway obstructionChronic obstructive pulmonary diseaseEmphysemaForced expiratory volumeMaximal Midexpiratory flow ratePulmonary function testsSpirometry

Identifiers

PMID30454050
PMCPMC6245799
OpenAlexW2901606436

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.