Evidence map›Paper›PMID 30453998›Full record

ArticleJournal of neuroinflammation2018

Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells.

Soraya Wilke Saliba, Hannah Jauch, Brahim Gargouri, Albrecht Keil, Thomas Hurrle, Nicole Volz, Florian Mohr, Mario van der Stelt, Stefan Bräse, Bernd L Fiebich

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
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  3. Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions.Liver international : official journal of the International Association for the Study of the Liver · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Soraya Wilke SalibaNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Hannah JauchNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Brahim GargouriNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Albrecht KeilNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Thomas HurrleInstitute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Nicole VolzInstitute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Florian MohrInstitute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Mario van der SteltDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
Stefan BräseInstitute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Bernd L FiebichNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. bernd.fiebich@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0002-9261-6771
Karlsruhe Institute of Technology · DEUniversity of Freiburg · DELeiden University · NLUniversity Medical Center Freiburg · DE

Funding

Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg none
6 · The paper itself

Abstract

backgroundNeuroinflammation plays a vital role in Alzheimer's disease and other neurodegenerative conditions. Microglia are the resident mononuclear immune cells of the central nervous system, and they play essential roles in the maintenance of homeostasis and responses to neuroinflammation. The orphan G-protein-coupled receptor 55 (GPR55) has been reported to modulate inflammation and is expressed in immune cells such as monocytes and microglia. However, its effects on neuroinflammation, mainly on the production of members of the arachidonic acid pathway in activated microglia, have not been elucidated in detail.

methodsIn this present study, a series of coumarin derivatives, that exhibit GPR55 antagonism properties, were designed. The effects of these compounds on members of the arachidonic acid cascade were studied in lipopolysaccharide (LPS)-treated primary rat microglia using Western blot, qPCR, and ELISA.

resultsWe demonstrate here that the various compounds with GPR55 antagonistic activities significantly inhibited the release of PGE

conclusionsOur results suggest that KIT 17 is acting as an inverse agonist on GPR55 independent of the endocannabinoid system. Targeting GPR55 might be a new therapeutic option to treat neurodegenerative diseases with a neuroinflammatory background such as Alzheimer's disease, Parkinson, and multiple sclerosis (MS).

Indexed as

AnimalsAnimals, NewbornAnti-Inflammatory AgentsCells, CulturedCerebral CortexCoumarinsCyclooxygenase 1Cyclooxygenase 2DinoprostoneDose-Response Relationship, DrugEnzyme InhibitorsLipopolysaccharidesMembrane ProteinsMicrogliaProstaglandin-E SynthasesRatsAnti-Inflammatory AgentscoumarinCoumarinsCyclooxygenase 1Cyclooxygenase 2DinoprostoneEnzyme InhibitorsGPR55 protein, ratLipopolysaccharidesMembrane ProteinsProstaglandin-E SynthasesPtges protein, mousePtgs1 protein, mousePtgs2 protein, mouseReceptors, CannabinoidReceptors, G-Protein-CoupledCyclooxygenaseGPR55MicrogliaNeuroinflammationProstaglandin E2

Identifiers

PMID30453998
PMCPMC6240959
OpenAlexW2900890015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.