Trial reportJournal of cardiothoracic surgery2018
Long-term performance of an external stent for saphenous vein grafts: the VEST IV trial.
Trial report in Journal of cardiothoracic surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01415245 (Vein External Support Trial), which is not on this map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vein External Support Trial
Who cites it
31 citing papers in PubMed.
- Propensity-matched analysis of the impact of saphenous vein graft external stenting on clinical outcomes in coronary bypass surgery: The RESTART study.JTCVS open · 2025Article
- Venous external support enhanced coronary artery bypass grafting: a multicentric cohort experience.Journal of cardiothoracic surgery · 2025Article
- Nanomedicine-based strategies for the treatment of vein graft disease.Nature reviews. Cardiology · 2025Review
- Nano-based perivascular intervention sustains a nine-month long-term suppression of intimal hyperplasia in vein grafts.Bioactive materials · 2025Article
- 'No-touch' or 'soft-touch' vein graft harvesting for CABG.Indian journal of thoracic and cardiovascular surgery · 2025Article
- External Support of Autologous Internal Jugular Vein Grafts with FRAME Mesh in a Porcine Carotid Artery Model.Biomedicines · 2024Article
- External stenting for saphenous vein grafts reduces early postoperative graft failure.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Techniques and Technologies to Improve Vein Graft Patency in Coronary Surgery.Medical sciences (Basel, Switzerland) · 2024Review
- Consensus statement-graft treatment in cardiovascular bypass graft surgery.Frontiers in cardiovascular medicine · 2024Article
- Improvement of the outcome of the saphenous vein graft when connected to the internal thoracic artery.Frontiers in cardiovascular medicine · 2024Article
- External Stenting for Saphenous Vein Grafts in Coronary Surgery: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Article
- The VEST External Support for Saphenous Vein Grafts in Coronary Surgery: A Review of Randomized Clinical Trials.Journal of cardiovascular development and disease · 2023Review
- Apolipoprotein A-I vascular gene therapy reduces vein-graft atherosclerosis.Molecular therapy. Methods & clinical development · 2023Article
- VEST III trial - should we support the vein grafts?Indian journal of thoracic and cardiovascular surgery · 2023Article
- Angiographic Outcomes for Arterial and Venous Conduits Used in CABG.Journal of clinical medicine · 2023Review
- Editorial comment on "current practice of saphenous vein graft harvesting in coronary artery bypass graft surgery: an Indian survey".Indian journal of thoracic and cardiovascular surgery · 2023Article
- The biomechanics and prevention of vein graft failure in coronary revascularization.Vessel plus · 2023Article
- Reply from authors: The perivascular adipose tissue is a versatile "jacket" that the saphenous vein wears inherently.JTCVS techniques · 2022Article
- Specific Graft Treatment Solution Enhances Vascular Endothelial Function.Reviews in cardiovascular medicine · 2022Article
- Biodegradable external wrapping promotes favorable adaptation in an ovine vein graft model.Acta biomaterialia · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExternally stenting saphenous vein grafts reduces intimal hyperplasia, improves lumen uniformity and reduces oscillatory shear stress 1 year following surgery. The present study is the first to present the longer-term (4.5 years) performance and biomechanical effects of externally stented saphenous vein grafts.
methodsThirty patients previously implanted with the VEST external stent in the randomized, within-patient-controlled VEST I study were followed up for adverse events; 21 of these were available to undergo coronary angiography and intravascular ultrasound.
resultsTwenty-one stented and 29 nonstented saphenous vein grafts were evaluated by angiography and ultrasound at 4.5 ± 0.3 years. Vein graft failure rates were comparable between stented and nonstented grafts (30 and 23% respectively; p = 0.42). All failures were apparent at 1 year except for one additional nonstented failure at 4.5 years. In patent vein grafts, Fitzgibbon perfect patency remained significantly higher in the stented versus nonstented vein grafts (81 and 48% respectively, p = 0.002), while intimal hyperplasia area (4.27 mm
conclusionsExternal stenting mitigates saphenous vein graft remodeling and significantly reduces diffuse intimal hyperplasia and the development of lumen irregularities 4.5 years after coronary artery bypass surgery. Close conformity of the stent to the vessel wall appears to be an important factor.
trial registrationNCT01415245 . Registered 11 August 2011.
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