SynthesisBMC medical ethics2018
A comprehensive systematic review of stakeholder attitudes to alternatives to prospective informed consent in paediatric acute care research.
Synthesis in BMC medical ethics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Views on consent approaches used in emergency and critical care research: a rapid, systematic review.Trials · 2026Pooled it
- Pooled it
- Pooled it
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- Can non-pharmacological comfort care replace fentanyl in LISA? The NONA-LISA feasibility study.Pediatric research · 2026Trial
- Alternative consent methods used in the multinational, pragmatic, randomised clinical trial SafeBoosC-III.Trials · 2024Trial
- Attitudes of patients and family members towards deferred and waived consent in ECPR research, an ancillary study of the INCEPTION trial.Resuscitation plus · 2026Article
- Community Acceptance of a Pediatric Prehospital Exception From Informed Consent Trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Article
- Insisting on prospective consent in paediatric critical care research may be throwing the baby out with the bathwater.Journal of paediatrics and child health · 2022Article
- Informed consent in dentistry and medicine in Spain: Practical considerations and legality.Medicina oral, patologia oral y cirugia bucal · 2022Article
- The acceptability of delayed consent for prehospital emergency care research in the Western Cape province of South Africa.PloS one · 2022Article
- Simultaneous Heart Rate Variability and Electroencephalographic Monitoring in Children in the Emergency Department.Journal of child & adolescent trauma · 2021Article
- A Formative Qualitative Study on the Acceptability of Deferred Consent in Adult Emergency Care Research in Malawi.Journal of empirical research on human research ethics : JERHRE · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA challenge of performing research in the paediatric emergency and acute care setting is obtaining valid prospective informed consent from parents. The ethical issues are complex, and it is important to consider the perspective of participants, health care workers and researchers on research without prospective informed consent while planning this type of research.
methodsWe performed a systematic review according to PRISMA guidelines, of empirical evidence relating to the process, experiences and acceptability of alternatives to prospective informed consent, in the paediatric emergency or acute care setting. Major medical databases and grey sources were searched and results were screened and assessed against eligibility criteria by 2 authors, and full text articles of relevant studies obtained. Data were extracted onto data collection forms and imported into data management software for analysis.
resultsThirteen studies were included in the review consisting of nine full text articles and four abstracts. Given the heterogeneity of the methods, results could not be quantitatively combined for meta-analysis, and qualitative results are presented in narrative form, according to themes identified from the data. Major themes include capacity of parents to provide informed consent, feasibility of informed consent, support for alternatives to informed consent, process issues, modified consent process, child death, and community consultation.
conclusionOur review demonstrated that children, their families, and health care staff recognise the requirement for research without prior consent, and are generally supportive of enrolling children in such research with the provisions of limiting risk, and informing parents as soon as possible. Australian data and perspectives of children are lacking and represent important knowledge gaps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.