Evidence map›Paper›PMID 30453686›Full record

ReviewNutrients2018

Gluten-Free Diet in Celiac Disease-Forever and for All?

Alice Itzlinger, Federica Branchi, Luca Elli, Michael Schumann

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 77 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 7 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05923346 nacompletednot on this mapstarted 2022, after this paper: background citation

Educational Intervention on Celiac Disease and Gluten-free Diet Through Social Networks (GLUTLEARN Project).

TypeinterventionalSponsorUniversity of the Basque Country (UPV/EHU)Ran2022 to 2023Enrolled93ConditionsCeliac DiseaseArmsGLUTLEARN
NCT06164548 unknown statusnot on this mapstarted 2024, after this paper: background citation

Celiac Disease Among Egyptian Children With Unexplained Short Stature

TypeobservationalSponsorAssiut UniversityRan2024 to 2025Enrolled100ConditionsCeliac Disease
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 7 syntheses or guidelines pooled it, 133 citations in OpenAlex.

  1. Pooled it
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  8. Trial
  9. Novel probiotic preparation withMicrobiology spectrum · 2024
    Trial
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  20. Celiac Disease: Beyond Diet and Food Awareness.Foods (Basel, Switzerland) · 2025
    Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Alice ItzlingerDivision of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, 12203 Berlin, Germany. alice.itzlinger@charite.de.
Federica BranchiDivision of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, 12203 Berlin, Germany. federica.branchi@charite.de.
Luca ElliCenter for the Prevention and Diagnosis of Celiac Disease, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. luca.elli@policlinico.mi.it.
Michael SchumannDivision of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, 12203 Berlin, Germany. michael.schumann@charite.de.
Charité - Universitätsmedizin Berlin · DEFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · IT

Funding

Deutsche Forschungsgemeinschaft GRK 2318 and TRR241European Crohn's and Colitis Organization ECCO Fellowship 2017
6 · The paper itself

Abstract

The gluten-free diet is the only effective treatment available for celiac disease. However, it is difficult to adhere to and a closer look on the diet's implementation and indications reveals several ambiguities: Not only is there controversy on the threshold of gluten that can be tolerated in the frame of a strict gluten-free diet, but it is also unclear whether the gluten-free diet is an appropriate treatment in patient subgroups with asymptomatic or potential celiac disease. Reports from a number of research groups suggest that a certain proportion of patients may effectively develop tolerance to gluten and thus become suitable for gluten reintroduction over time. In this review, we set out to create an overview about the current state of research as regards the definition of a strict gluten-free diet in terms of the gluten thresholds considered tolerable and the indication for a gluten-free diet in the absence of histological abnormalities or symptoms. Furthermore, we discuss the concept that a gluten-free diet must be followed for life by all patients.

Indexed as

Celiac DiseaseDiet, Gluten-FreeGlutensHumansIntestinal MucosaTime FactorsTreatment OutcomeGlutensadherenceglutenmucosal recoveryserologythresholdvillous atrophy

Identifiers

PMID30453686
PMCPMC6267495
OpenAlexW2901273257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.