Evidence map›Paper›PMID 30453631›Full record

ReviewMolecules (Basel, Switzerland)2018

DNA Replication: From Radioisotopes to Click Chemistry.

Anna Ligasová, Karel Koberna

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Bioconjugate chemistry · 2023
    Article
  5. Basic Methods of Cell Cycle Analysis.International journal of molecular sciences · 2023
    Review
  6. Nucleotide excision repair removes thymidine analog 5-ethynyl-2'-deoxyuridine from the mammalian genome.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anna LigasováFaculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University in Olomouc, Hněvotínská 5, 779 00 Olomouc, Czech Republic. anna.ligasova@upol.cz.ORCID 0000-0002-1564-3768
Karel KobernaFaculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University in Olomouc, Hněvotínská 5, 779 00 Olomouc, Czech Republic. karel.koberna@upol.cz.
Institute of Molecular and Translational Medicine · CZ

Funding

Agentura Pro Zdravotnický Výzkum České Republiky 15-31604AEuropean Regional Development Fund CZ.02.1.01/0.0/0.0/16_019/0000868Ministerstvo Školství, Mládeže a Tělovýchovy LO1304
6 · The paper itself

Abstract

The replication of nuclear and mitochondrial DNA are basic processes assuring the doubling of the genetic information of eukaryotic cells. In research of the basic principles of DNA replication, and also in the studies focused on the cell cycle, an important role is played by artificially-prepared nucleoside and nucleotide analogues that serve as markers of newly synthesized DNA. These analogues are incorporated into the DNA during DNA replication, and are subsequently visualized. Several methods are used for their detection, including the highly popular click chemistry. This review aims to provide the readers with basic information about the various possibilities of the detection of replication activity using nucleoside and nucleotide analogues, and to show the strengths and weaknesses of those different detection systems, including click chemistry for microscopic studies.

Indexed as

DNA ReplicationClick ChemistryCopperDNAHalogenationImmunohistochemistryIn Situ HybridizationIsotope LabelingNucleosidesNucleotidesRadioisotopesResearchCopperDNANucleosidesNucleotidesRadioisotopesclick chemistryindirect immunocytochemistryisotopesnucleoside and nucleotide analogues

Identifiers

PMID30453631
PMCPMC6278288
OpenAlexW2901617531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.