Evidence map›Paper›PMID 30453544›Full record

ReviewInternational journal of molecular sciences2018

Prevention Is the Best Treatment: The Case for Understanding the Transition from Monoclonal Gammopathy of Undetermined Significance to Myeloma.

Michael H Tomasson, Mahmoud Ali, Vanessa De Oliveira, Qian Xiao, Yogesh Jethava, Fenghuang Zhan, Adam M Fitzsimmons, Melissa L Bates

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. [Progress of interleukin-6-related antibodies in the treatment of multiple myeloma].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2021
    Article
  6. Everyone must be able to breathe: a plan to support diversity and inclusion in respiratory physiology.American journal of physiology. Lung cellular and molecular physiology · 2020
    Article
  7. Article
  8. Article
  9. Chronic intermittent hypoxia enhances disease progression in myeloma-resistant mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Michael H TomassonDepartment of Internal Medicine, Hematology, Oncology, and Bone Marrow Transplant Division, University of Iowa, Iowa City, IA 52242, USA. michael-tomasson@uiowa.edu.ORCID 0000-0003-4518-7123
Mahmoud AliDepartment of Internal Medicine, Hematology, Oncology, and Bone Marrow Transplant Division, University of Iowa, Iowa City, IA 52242, USA. Mahmoud-ali@uiowa.edu.ORCID 0000-0001-5905-5936
Vanessa De OliveiraDepartment of Internal Medicine, Hematology, Oncology, and Bone Marrow Transplant Division, University of Iowa, Iowa City, IA 52242, USA. vanessa-deoliveira@uiowa.edu.
Qian XiaoDepartment of Health Human Physiology, University of Iowa, Iowa City, IA 52242, USA. qian-xiao@uiowa.edu.
Yogesh JethavaDepartment of Internal Medicine, Hematology, Oncology, and Bone Marrow Transplant Division, University of Iowa, Iowa City, IA 52242, USA. yogesh-jethava@uiowa.edu.
Fenghuang ZhanDepartment of Internal Medicine, Hematology, Oncology, and Bone Marrow Transplant Division, University of Iowa, Iowa City, IA 52242, USA. Fenghuang-Zhan@uiowa.edu.
Adam M FitzsimmonsGraduate Program in Molecular Medicine, University of Iowa, Iowa City, IA 52242, USA. adam-fitzsimmons@uiowa.edu.
Melissa L BatesHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA. melissa-bates@uiowa.edu.ORCID 0000-0002-2605-0984
University of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
American Cancer Society IRG-15-176-40
6 · The paper itself

Abstract

Multiple myeloma is an invariably fatal cancer of plasma cells. Despite tremendous advances in treatment, this malignancy remains incurable in most individuals. We postulate that strategies aimed at prevention have the potential to be more effective in preventing myeloma-related death than additional pharmaceutical strategies aimed at treating advanced disease. Here, we present a rationale for the development of prevention therapy and highlight potential target areas of study.

Indexed as

Disease ProgressionHumansMonoclonal Gammopathy of Undetermined SignificanceMultiple MyelomaMutationRisk Factorsmonoclonal gammopathy of undetermined significancemultiple myelomaplasma cell diseasepreventiontherapy

Identifiers

PMID30453544
PMCPMC6274834
OpenAlexW2900747275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.