Evidence map›Paper›PMID 30453499›Full record

ArticleViruses2018

Intramuscular Exposure of

Kendra J Alfson, Laura E Avena, Michael W Beadles, Gabriella Worwa, Melanie Amen, Jean L Patterson, Ricardo Carrion, Anthony Griffiths

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kendra J AlfsonDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. kalfson@txbiomed.org.
Laura E AvenaDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. lavena@bu.edu.
Michael W BeadlesDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. mbeadles41@gmail.com.
Gabriella WorwaDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. gabriella.worwa@nih.gov.ORCID 0000-0001-7485-2204
Melanie AmenDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. melanieamen@yahoo.com.
Jean L PattersonDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. jpatters@txbiomed.org.ORCID 0000-0001-8069-8098
Ricardo CarrionDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. rcarrion@txbiomed.org.
Anthony GriffithsDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. ahgriff@bu.edu.
Texas Biomedical Research Institute · USBoston University · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
NIH HHS P51 OD011133U.S. Department of Defense W911QY-12-C-0076
6 · The paper itself

Abstract

The filoviruses Ebola virus (EBOV) and Sudan virus (SUDV) can cause severe diseases, and there are currently no licensed countermeasures available for use against them. Transmission occurs frequently via contact with bodily fluids from infected individuals. However, it can be difficult to determine when or how someone became infected, or the quantity of infectious virus to which they were exposed. Evidence suggests the infectious dose is low, but the majority of published studies use high exposure doses. This study characterized the outcome of exposure to a low dose of EBOV or SUDV, using a

Indexed as

Disease Models, AnimalAnimalsEbolavirusHemorrhagic Fever, EbolaInjections, IntramuscularMacaca fascicularisSurvival AnalysisEbola viruslow dosenonhuman primate modelSudan virus

Identifiers

PMID30453499
PMCPMC6267154
OpenAlexW2900823855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.