ArticleAtherosclerosis2019
Life course trajectories of cardiovascular risk: Impact on atherosclerotic and metabolic indicators.
Article in Atherosclerosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Serum Zinc Levels in Early Life and Risk of Elevated Carotid Intima-Media Thickness: An 8-Year Prospective Study.Cardiovascular toxicology · 2026Article
- Adolescent Cardiovascular Risk Trajectories and Later-Life Maternal Morbidity.JAMA network open · 2025Article
- Carotid intima medial thickness and its association with cardiometabolic risk factors in children with overweight and obesity: a hospital-based cross-sectional study.The British journal of nutrition · 2025Article
- Trajectories of cardiovascular risk predict pregnancy outcomes: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study.Paediatric and perinatal epidemiology · 2024Article
- Association between blood pressure multi-trajectory and cardiovascular disease among a Chinese elderly medical examination population.Frontiers in cardiovascular medicine · 2024Article
- The longitudinal association between neighbourhood quality and cardiovascular risk factors among youth receiving obesity treatment.Pediatric obesity · 2023Article
- The 30-year cardiovascular risk trajectories and their independently associated factors in participants of a Brazilian cohort (CUME Study).Cadernos de saude publica · 2023Article
- Midlife Neuropsychological Profiles and Associated Vascular Risk: The Bogalusa Heart Study.Journal of Alzheimer's disease : JAD · 2023Article
- Carotid Intima-Media Thickness and Midlife Cognitive Function: Impact of Race and Social Disparities in the Bogalusa Heart Study.Neurology · 2022Article
- Article
- Influential Periods in Longitudinal Clinical Cardiovascular Health Scores.American journal of epidemiology · 2021Article
- Multi-trajectories of lipid indices with incident cardiovascular disease, heart failure, and all-cause mortality: 23 years follow-up of two US cohort studies.Journal of translational medicine · 2021Article
- The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.Obesity (Silver Spring, Md.) · 2021Article
- Physical Activity, Sport Practice and Cardiovascular Risk Factors in Workers From a Public Hospital: A Trajectory Analysis.Frontiers in cardiovascular medicine · 2021Article
- Exercise and Carotid Properties in the Young-The KiGGS-2 Study.Frontiers in cardiovascular medicine · 2021Article
- Challenges and Opportunities for the Prevention and Treatment of Cardiovascular Disease Among Young Adults: Report From a National Heart, Lung, and Blood Institute Working Group.Journal of the American Heart Association · 2020Review
- Long-term trajectories of BMI predict carotid stiffness and plaque volume in type 2 diabetes older adults: a cohort study.Cardiovascular diabetology · 2020Article
- Long-term BMI change trajectories in Chinese adults and its association with the hazard of type 2 diabetes: evidence from a 20-year China Health and Nutrition Survey.BMJ open diabetes research & care · 2020Article
- Spatial clusters of cancer incidence: analyzing 1940 census data linked to 1966-2017 cancer records.Cancer causes & control : CCC · 2020Article
- Rationale and design of "Hearts & Parks": study protocol for a pragmatic randomized clinical trial of an integrated clinic-community intervention to treat pediatric obesity.BMC pediatrics · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
aimsIn this analysis, we estimated population-level trajectory groups of life course cardiovascular risk to explore their impact on mid-life atherosclerotic and metabolic outcomes.
methodsThis prospective study followed n = 1269 Bogalusa Heart participants, each with at least 4 study visits from childhood in 1973 through adulthood in 2016. We used discrete mixture modeling to determine trajectories of cardiovascular risk percentiles from childhood to adulthood. Outcomes included mid-life subclinical atherosclerotic measures [(carotid intima-media thickness (cIMT), pulse wave velocity (PWV)], metabolic indicators [(diabetes and body mass index (BMI)], and short physical performance battery (SPPB).
resultsBetween the mean ages of 9.6-48.3 years, we estimated five distinct trajectory groups of life course cardiovascular risk (High-Low, High-High, Mid-Low, Low-Low, and Low-High). Adult metabolic and vascular outcomes were significantly determined by life course cardiovascular risk trajectory groups (all p < 0.01). Those in the High-Low group had lower risks of diabetes (20% vs. 28%, respectively; p = .12) and lower BMIs (32.4 kg/m
conclusionsWe found considerable movement between low- and high-relative cardiovascular risk strata over the life course. Children who improved their relative cardiovascular risk over the life course achieved better mid-life atherosclerotic health despite maintaining relatively poor metabolic health through adulthood.
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