Evidence map›Paper›PMID 30452941›Full record

ReviewProgress in neuro-psychopharmacology & biological psychiatry2019

Genomic updates in understanding PTSD.

Sumeet Sharma, Kerry J Ressler

Abstract readReview
In one paragraph

Review in Progress in neuro-psychopharmacology & biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Pre-trauma cognitive traits predict fear generalization and associated prefrontal functioning in a longitudinal rodent model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Epigenetics, Resilience, Protective Factors and Factors Promoting Positive Outcomes: A Scoping Review.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. [Comorbidity of posttraumatic stress disorder and addiction from a biopsychosocial perspective].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2022
    Article
  8. Review
  9. Genetic Differences between Physical Injury Patients With and Without Post-traumatic Syndrome: Focus on Secondary Findings and Potential Variants Revealed by Whole Exome Sequencing.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021
    Article
  10. Article
  11. TheFrontiers in psychiatry · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Impact of ADCYAP1R1 genotype on longitudinal fear conditioning in children: interaction with trauma and sex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sumeet SharmaNeuroscience Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States; McLean Hospital, Division of Depression and Anxiety, Belmont, MA, United States.
Kerry J ResslerMcLean Hospital, Division of Depression and Anxiety, Belmont, MA, United States; Harvard Medical School, Boston, MA, United States; Neuroscience Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States. Electronic address: kressler@mclean.harvard.edu.

Funding

Psychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M
Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala PathwaysR01MH108665 · NIMH · MCLEAN HOSPITAL · PI BOLSHAKOV, VADIM, RESSLER, KERRY J. · 2016 to 2025
$7.5M
3/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109536 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W, HUCKINS, LAURA MARIANNE · 2016 to 2020
$2.7M
4/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124847 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M, SEBAT, JONATHAN · 2021 to 2025
$2.1M
Genetic and Trauma-Related Risk Factors for PTSD: From GWAS to FunctionR56MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2015 to 2015
$148k
NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH108665NIMH NIH HHS R01 MH124847NIMH NIH HHS R56 MH071537NIMH NIH HHS U01 MH109536
6 · The paper itself

Abstract

Twin studies as well as more recent genetics-based heritability analyses demonstrate that up to 40 to 50% of the variance in predicting PTSD following trauma is heritable. However, most of the specific gene pathways and mechanism that mediate risk vs. resilience for PTSD following trauma exposure have yet to be elucidated. This review will examine the latest results from large scale Genome-wide association studies as well as other approaches aimed at understanding mechanisms of development of and recovery from PTSD.

Indexed as

AnimalsGene-Environment InteractionGenetic Predisposition to DiseaseHumansStress Disorders, Post-TraumaticAnxietyDepressionEpigeneticGene-by-environment interactionPTSDStressTrauma

Identifiers

PMID30452941
PMCPMC6431237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.