ArticleResuscitation2019
Partial pressure of arterial carbon dioxide after resuscitation from cardiac arrest and neurological outcome: A prospective multi-center protocol-directed cohort study.
Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph
Article in Resuscitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07258823 (Study on the Effectiveness of Continuous Compression-synchronous Ventilation), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR) in the ACLS Stage of Cardiopulmonary Resuscitation (ACLS) Based on the Bionic Concept to Explore the Best Mechanical Ventilation Strategy
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 5. Post-cardiac arrest care.Clinical and experimental emergency medicine · 2021Guideline
- Therapeutic hypercapnia after cardiac arrest: still promising or time to move on?Intensive care medicine experimental · 2026Review
- Extracorporeal Membrane Oxygenation in Refractory Cardiac Arrest: Current Evidence, Clinical Pathways and Future Directions.Life (Basel, Switzerland) · 2026Review
- Acidemia predicts mortality independently of lactate levels in patients after cardiac arrest.Resuscitation plus · 2026Article
- [Does Arterial Blood Gas Analysis Predict an Adverse Course in Patients Admitted with Isolated Diaphyseal Femur Fractures?]Revista brasileira de ortopedia · 2025Article
- Does Arterial Blood Gas Analysis Predict an Adverse Course in Patients Admitted with Isolated Diaphyseal Femur Fractures?Revista brasileira de ortopedia · 2025Article
- Lactate and pH as Independent Biomarkers for Prognosticating Meaningful Post-out-of-Hospital Cardiac Arrest Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Post-Thrombectomy Mild Hypercapnia State Prevents Poor Outcome by Reducing Infarct Progression.Brain and behavior · 2025Article
- Ventilation and Oxygenation During and After Adult Cardiopulmonary Resuscitation: Changing Paradigms.Respiratory care · 2024Review
- Management of Patients With Cardiac Arrest Requiring Interfacility Transport: A Scientific Statement From the American Heart Association.Circulation · 2024Review
- Midazolam for Post-Arrest Sedation in Pre-Hospital Emergency Care—a Multicenter Propensity Score Analysis.Deutsches Arzteblatt international · 2024Observational
- Association among blood pressure, end-tidal carbon dioxide, peripheral oxygen saturation and mortality in prehospital post-resuscitation care.Resuscitation plus · 2024Article
- Target flow deviations on the cardiopulmonary bypass cause postoperative delirium in cardiothoracic surgery-a retrospective study evaluating temporal fluctuations of perfusion data.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement from the American Heart Association and Neurocritical Care Society.Neurocritical care · 2024Article
- Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement From the American Heart Association and Neurocritical Care Society.Circulation · 2024Review
- Optimal inhaled oxygen and carbon dioxide concentrations for post-cardiac arrest cerebral reoxygenation and neurological recovery.iScience · 2023Article
- Chloride Reduction Therapy with Furosemide: Short-Term Effects in Children with Acute Respiratory Failure.Journal of pediatric intensive care · 2023Article
- Survival with Good Neurological Outcome despite Prolonged Cardiopulmonary Resuscitation and Extreme Acidosis after Out-of-Hospital Cardiac Arrest Due to Acute Myocardial Infarction: A Case Report and Review of the Literature.Clinics and practice · 2023Article
- Oxygen Supplementation and Hyperoxia in Critically Ill Cardiac Patients: From Pathophysiology to Clinical Practice.JACC. Advances · 2022Article
- The association of modifiable mechanical ventilation settings, blood gas changes and survival on extracorporeal membrane oxygenation for cardiac arrest.Resuscitation · 2022Observational
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
J Hope KilgannonThe Department of Emergency Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, United States.
Benton R HunterThe Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.
Michael A PuskarichThe Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, United States.
Lisa SheaThe Department of Medicine, Division of Critical Care Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, United States.
Brian M FullerDepartments of Emergency Medicine and Anesthesiology, Division of Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Christopher JonesThe Department of Emergency Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, United States.
Michael DonninoThe Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Jeffrey A KlineThe Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.
Alan E JonesThe Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, United States.
Nathan I ShapiroThe Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Benjamin S AbellaThe Center for Resuscitation Science and Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Stephen TrzeciakThe Department of Emergency Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, United States; The Department of Medicine, Division of Critical Care Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, United States.
Brian W RobertsThe Department of Emergency Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, United States. Electronic address: roberts-brian-w@cooperhealth.edu.
Cooper University Hospital · USBeth Israel Deaconess Medical Center · USIndiana University School of MedicineUniversity of Mississippi Medical Center · USUniversity of Pennsylvania · USWashington University in St. Louis · US
Funding
Neurological and cognitive effects of hyperoxia after cardiac arrestR01HL112815 · NHLBI · COOPER UNIVERSITY HOSPITAL · PI TRZECIAK, STEPHEN WALTER · 2013 to 2016
$2.4MPostresuscitation PaCO2 and neurological outcome after cardiac arrestK23HL126979 · NHLBI · ROWAN UNIVERSITY · PI ROBERTS, BRIAN W · 2015 to 2019
$769kNHLBI NIH HHS K23 HL126979NHLBI NIH HHS L30 HL133982NHLBI NIH HHS R01 HL112815
Abstract
aimsPartial pressure of arterial carbon dioxide (PaCO
methodsA prospective protocol-directed cohort study across six hospitals. INCLUSION CRITERIA: age ≥18, non-traumatic cardiac arrest, mechanically ventilated after return of spontaneous circulation (ROSC), and receipt of targeted temperature management. Per protocol, PaCO
resultsOf the 280 patients included, the median (interquartile range) PaCO
conclusionPaCO
Indexed as
Carbon DioxideCardiopulmonary ResuscitationHeart ArrestHypercapniaHypothermia, InducedNervous System DiseasesAcidosisBlood Gas AnalysisCohort StudiesFemaleHumansMaleMiddle AgedNeuroprotectionOutcome Assessment, Health CareOxygenCarbon DioxideOxygenCardiac arrestHeart arrestPaCO(2)Partial pressure of arterial carbon dioxide
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT07258823ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.