Evidence map›Paper›PMID 30452713›Full record

Trial reportThe Journal of infectious diseases2019

The Effect of Helminths on Granulocyte Activation: A Cluster-Randomized Placebo-Controlled Trial in Indonesia.

Karin de Ruiter, Dicky L Tahapary, Erliyani Sartono, Thomas B Nutman, Johannes W A Smit, Leo Koenderman, Taniawati Supali, Maria Yazdanbakhsh

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Karin de RuiterDepartment of Parasitology, Leiden University Medical Center, The Netherlands.
Dicky L TahaparyDepartment of Parasitology, Leiden University Medical Center, The Netherlands.
Erliyani SartonoDepartment of Parasitology, Leiden University Medical Center, The Netherlands.
Thomas B NutmanLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Johannes W A SmitDepartment of Internal Medicine, Leiden University Medical Center, The Netherlands.
Leo KoendermanLaboratory of Translational Immunology, University Medical Center Utrecht, The Netherlands.
Taniawati SupaliDepartment of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Maria YazdanbakhshDepartment of Parasitology, Leiden University Medical Center, The Netherlands.
Leiden University Medical Center · NLNational Institutes of Health · USRadboud University Nijmegen · NLUniversity Medical Center Utrecht · NLUniversity of Indonesia · ID

Funding

Immunoregulation /Immune Recognition In Filarial/Nonfilarial Parasitic InfectionZIAAI000197 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$23.4M
6 · The paper itself

Abstract

backgroundEosinophils are a prominent cell type in the host response to helminths, and some evidence suggests that neutrophils might also play a role. However, little is known about the activation status of these granulocytes during helminth infection.

methodsWe analyzed the expression of eosinophil and neutrophil activation markers in peripheral blood by flow cytometry and measured serum levels of eosinophil granule proteins in 300 subjects residing in an area endemic for soil-transmitted helminths (STH). The data generated are on samples before and after 1 year of 3-monthly albendazole treatment.

resultsAnthelmintic treatment significantly reduced the prevalence of STH. While eosinophil numbers were significantly higher in STH-infected compared to uninfected subjects and significantly decreased following albendazole treatment, there was no effect exerted by the helminths on either eosinophil nor neutrophil activation. Although at baseline eosinophil granule protein levels were not different between STH-infected and uninfected subjects, treatment significantly reduced the levels of eosinophil-derived neurotoxin (EDN) in those infected at baseline.

conclusionsThese results show that besides decreasing eosinophil numbers, anthelmintic treatment does not significantly change the activation status of eosinophils, nor of neutrophils, and the only effect seen was a reduction in circulating levels of EDN. CLINICAL TRIALS REGISTRATION: http://www.isrctn.com/ISRCTN75636394.

Indexed as

AdultAlbendazoleAnthelminticsAntigens, CDAntigens, Differentiation, T-LymphocyteAsian PeopleBiomarkersCase-Control StudiesCD11b AntigenCD69 AntigensCell Adhesion MoleculesEosinophil Cationic ProteinEosinophil-Derived NeurotoxinEosinophil Granule ProteinsEosinophil Major Basic ProteinEosinophilsAlbendazoleAnthelminticsAntigens, CDAntigens, Differentiation, T-LymphocyteBiomarkersCD11b AntigenCD69 AntigensCEACAM8 protein, humanCell Adhesion MoleculesCR1 protein, humanEosinophil Cationic ProteinEosinophil-Derived NeurotoxinEosinophil Granule ProteinsEosinophil Major Basic ProteinGPI-Linked ProteinsITGAM protein, humanLectins, C-TypeL-SelectinReceptors, Complement 3bSELL protein, humanactivation markerseosinophilsgranular proteinshelminthsIndonesianeutrophils

Identifiers

PMID30452713
PMCPMC6775045
OpenAlexW2901548408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.