ArticleJAMA neurology2019
Prevalence and Severity of Alzheimer Disease in Individuals With Down Syndrome.
Article in JAMA neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Pharmacological Approaches to the Treatment of Dementia in Down Syndrome: A Systematic Review of Randomized Clinical Studies.Molecules (Basel, Switzerland) · 2022Pooled it
- Caregivers' Perspectives on Medical Management and Its Helpfulness in Down Syndrome.American journal of medical genetics. Part A · 2026Article
- Caregiver Interviews Regarding Health in Down Syndrome.American journal of medical genetics. Part A · 2026Observational
- Bothersome and Impactful Health Conditions in Children and Adolescents with Down Syndrome.The Journal of pediatrics · 2025Observational
- Differences in cholinergic terminal density in adults with Down syndrome compared to neurotypical controls measured by [Neurobiology of aging · 2025Article
- Age-Related Changes in the Cholinergic System in Adults with Down Syndrome Assessed Using [medRxiv : the preprint server for health sciences · 2024Article
- Health in Down syndrome: creating a conceptual model.Journal of intellectual disability research : JIDR · 2023Article
- Aging with Down Syndrome-Where Are We Now and Where Are We Going?Journal of clinical medicine · 2021Review
- Biomarkers show value of studying dementia in Down syndrome.Nature reviews. Neurology · 2021Article
- Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain.Journal of clinical medicine · 2021Article
- Blood Biomarkers for Alzheimer's Disease in Down Syndrome.Journal of clinical medicine · 2021Review
- Epilepsy in Down Syndrome: A Highly Prevalent Comorbidity.Journal of clinical medicine · 2021Review
- Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer's disease-related dysregulation.Clinical epigenetics · 2019Article
- Error in Results.JAMA neurology · 2019Article
Corrections and comments
- Comment on
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.