Evidence map›Paper›PMID 30451861›Full record

ArticleNature communications2018

Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions.

Thomas Philipp Hoernes, Klaus Faserl, Michael Andreas Juen, Johannes Kremser, Catherina Gasser, Elisabeth Fuchs, Xinying Shi, Aaron Siewert, Herbert Lindner, Christoph Kreutz and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Genes · 2023
    Article
  8. Article
  9. Review
  10. Synthesis of point-modified mRNA.Nucleic acids research · 2022
    Article
  11. Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of Rett syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats.International journal of molecular sciences · 2022
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Long Non-Coding RNA Epigenetics.International journal of molecular sciences · 2021
    Review
  20. The epitranscriptome beyond mNature reviews. Genetics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Thomas Philipp HoernesDivision of Genomics and RNomics, Biocenter, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Klaus FaserlDivision of Clinical Biochemistry, Biocenter, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Michael Andreas JuenInstitute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck, 6020, Innsbruck, Austria.
Johannes KremserInstitute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck, 6020, Innsbruck, Austria.
Catherina GasserInstitute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck, 6020, Innsbruck, Austria.
Elisabeth FuchsInstitute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck, 6020, Innsbruck, Austria.
Xinying ShiDepartment of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0314, USA.
Aaron SiewertInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Herbert LindnerDivision of Clinical Biochemistry, Biocenter, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Christoph KreutzInstitute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck, 6020, Innsbruck, Austria.
Ronald MicuraInstitute of Organic Chemistry and Center for Molecular Biosciences (CMBI), University of Innsbruck, 6020, Innsbruck, Austria.
Simpson JosephDepartment of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0314, USA.
Claudia HöbartnerInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Eric WesthofArchitecture and Reactivity of RNA, Institute of Molecular and Cellular Biology of the CNRS UPR9002/University of Strasbourg, Strasbourg, 67084, France.
Alexander HüttenhoferDivision of Genomics and RNomics, Biocenter, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Matthias David ErlacherDivision of Genomics and RNomics, Biocenter, Medical University of Innsbruck, 6020, Innsbruck, Austria. matthias.erlacher@i-med.ac.at.
Universität Innsbruck · ATInnsbruck Medical University · ATUniversity of California, San Diego · USUniversity of Würzburg · DEUniversité de Strasbourg · FR

Funding

Austrian Science Fund FWF P 22658Austrian Science Fund FWF P 30486
6 · The paper itself

Abstract

The precise interplay between the mRNA codon and the tRNA anticodon is crucial for ensuring efficient and accurate translation by the ribosome. The insertion of RNA nucleobase derivatives in the mRNA allowed us to modulate the stability of the codon-anticodon interaction in the decoding site of bacterial and eukaryotic ribosomes, allowing an in-depth analysis of codon recognition. We found the hydrogen bond between the N

Indexed as

Protein Biosynthesis2-AminopurineAnticodonBacteriophage T7Base SequenceCodonCytidineDNA-Directed RNA PolymerasesEscherichia coliHEK293 CellsHumansHydrogen BondingInosinePyridonesReceptor, Serotonin, 5-HT2CRibosomes2,6-diaminopurine2-AminopurineAnticodonbacteriophage T7 RNA polymeraseCodonCytidineDNA-Directed RNA PolymerasesInosinePyridonespyrimidin-2-one beta-ribofuranosideReceptor, Serotonin, 5-HT2CRNA, Transfer, GlyViral Proteins

Identifiers

PMID30451861
PMCPMC6242847
OpenAlexW2901907982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.