Evidence map›Paper›PMID 30451685›Full record

ArticleeLife2018

Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein.

Xiao-Man Liu, Akinori Yamasaki, Xiao-Min Du, Valerie C Coffman, Yoshinori Ohsumi, Hitoshi Nakatogawa, Jian-Qiu Wu, Nobuo N Noda, Li-Lin Du

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Guideline
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  3. Autophagy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Xiao-Man Liu *National Institute of Biological Sciences, Beijing, China.
Akinori Yamasaki *Institute of Microbial Chemistry, Tokyo, Japan.
Xiao-Min Du *National Institute of Biological Sciences, Beijing, China.
Valerie C CoffmanThe Ohio State University, Columbus, United States.
Yoshinori OhsumiUnit for Cell Biology, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.
Hitoshi NakatogawaSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.ORCID https://orcid.org/0000-0002-5828-0741
Jian-Qiu WuThe Ohio State University, Columbus, United States.
Nobuo N NodaInstitute of Microbial Chemistry, Tokyo, Japan.ORCID https://orcid.org/0000-0002-6940-8069
Li-Lin DuNational Institute of Biological Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-1028-7397
Microbial Chemistry Research Foundation · JPNational Institute of Biological Sciences, Beijing · CNThe Ohio State University · USTokyo Institute of Technology · JPBeijing Normal University · CN

Funding

Molecular Mechanisms of CytokinesisR01GM118746 · NIGMS · OHIO STATE UNIVERSITY · PI WU, JIAN-QIU · 2016 to 2025
$2.7M
NIGMS NIH HHS R01 GM118746
6 · The paper itself

Abstract

The ubiquitin-like protein Atg8, in its lipidated form, plays central roles in autophagy. Yet, remarkably, Atg8 also carries out lipidation-independent functions in non-autophagic processes. How Atg8 performs its moonlighting roles is unclear. Here we report that in the fission yeast

Indexed as

Amino Acid SequenceAutophagyAutophagy-Related Protein 8 FamilyLipidsMembrane ProteinsMutationPhylogenyProtein BindingProtein Interaction MappingProtein Structure, SecondarySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsStructure-Activity RelationshipVacuolesATG8 protein, S cerevisiaeautophagy associated protein Atg8, S pombeAutophagy-Related Protein 8 FamilyHfl1 protein, S pombeLipidsMembrane ProteinsSaccharomyces cerevisiae ProteinsSchizosaccharomyces pombe ProteinsAtg8autophagycell biologymolecular biophysicsS. cerevisiaeS. pombestructural biologyvacuole

Identifiers

PMID30451685
PMCPMC6279349
OpenAlexW2900558312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.