Evidence map›Paper›PMID 30451684›Full record

ArticleeLife2018

Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues.

Eglantine Heude, Marketa Tesarova, Elizabeth M Sefton, Estelle Jullian, Noritaka Adachi, Alexandre Grimaldi, Tomas Zikmund, Jozef Kaiser, Gabrielle Kardon, Robert G Kelly and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 81 citations in OpenAlex.

  1. Review
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  3. Harmonizing mouse anatomy terminology: a common language?Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
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  16. Insights and perspectives on the enigmatic alary muscles of arthropods.Frontiers in cell and developmental biology · 2023
    Review
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Eglantine HeudeDepartment of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France.
Marketa TesarovaCentral European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Elizabeth M SeftonDepartment of Human Genetics, University of Utah, Salt Lake City, United States.ORCID http://orcid.org/0000-0001-6481-612X
Estelle JullianAix-Marseille Université, CNRS UMR 7288, IBDM, Marseille, France.
Noritaka AdachiAix-Marseille Université, CNRS UMR 7288, IBDM, Marseille, France.ORCID http://orcid.org/0000-0002-9482-8436
Alexandre GrimaldiDepartment of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France.
Tomas ZikmundCentral European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Jozef KaiserCentral European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
Gabrielle KardonDepartment of Human Genetics, University of Utah, Salt Lake City, United States.
Robert G KellyAix-Marseille Université, CNRS UMR 7288, IBDM, Marseille, France.
Shahragim TajbakhshDepartment of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0003-1809-7202
Centre National de la Recherche Scientifique · FRCentral European Institute of Technology · CZUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vertebrates, head and trunk muscles develop from different mesodermal populations and are regulated by distinct genetic networks. Neck muscles at the head-trunk interface remain poorly defined due to their complex morphogenesis and dual mesodermal origins. Here, we use genetically modified mice to establish a 3D model that integrates regulatory genes, cell populations and morphogenetic events that define this transition zone. We show that the evolutionary conserved cucullaris-derived muscles originate from posterior cardiopharyngeal mesoderm, not lateral plate mesoderm, and we define new boundaries for neural crest and mesodermal contributions to neck connective tissue. Furthermore, lineage studies and functional analysis of

Indexed as

MorphogenesisAnimalsConnective TissueFemaleGene Expression Regulation, DevelopmentalMaleMammalsMesodermMice, KnockoutMice, TransgenicMicroscopy, ConfocalMuscle, SkeletalNeck MusclesSomitesT-Box Domain ProteinsX-Ray MicrotomographyT-Box Domain ProteinsTbx1 protein, mousecranial mesodermdevelopmental biologymouseneck myogenesisneural crestsomite

Identifiers

PMID30451684
PMCPMC6310459
OpenAlexW2949374859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.