ArticleBiochemistry2019
Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding.
Article in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity.Genes & development · 2026Article
- RNA-induced PRC2 inhibition depends on the sequence of bound RNA.Nature communications · 2026Article
- RNA-induced PRC2 inhibition depends on the sequence of bound RNA.Research square · 2025Article
- Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features ofbioRxiv : the preprint server for biology · 2025Article
- Phosphorylation powers plant Polycomb.Nature plants · 2025Article
- Structure-guided design and development of cyclic peptide allosteric activators of Polycomb Repressive Complex 2.bioRxiv : the preprint server for biology · 2025Article
- Activation of automethylated PRC2 by dimerization on chromatin.Molecular cell · 2024Article
- Structural basis for inactivation of PRC2 by G-quadruplex RNA.Science (New York, N.Y.) · 2023Article
- Survivin prevents the polycomb repressor complex 2 from methylating histone 3 lysine 27.iScience · 2023Article
- Review
- Review
- Structural insights into the interactions of Polycomb Repressive Complex 2 with chromatin.Biochemical Society transactions · 2021Review
- JMJD3: a critical epigenetic regulator in stem cell fate.Cell communication and signaling : CCS · 2021Review
- Cooperative DNA looping by PRC2 complexes.Nucleic acids research · 2021Article
- Polycomb Repressive Complex 2: a Dimmer Switch of Gene Regulation in Calvarial Bone Development.Current osteoporosis reports · 2020Review
- Dynamic Competition of Polycomb and Trithorax in Transcriptional Programming.Annual review of biochemistry · 2020Review
- Current outcomes when optimizing 'standard' sample preparation for single-particle cryo-EM.Journal of microscopy · 2019Article
- Polycomb repressive 2 complex-Molecular mechanisms of function.Protein science : a publication of the Protein Society · 2019Review
- PRC2 is high maintenance.Genes & development · 2019Review
- Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation.Molecular cell · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Polycomb group proteins are transcriptional repressors controlling gene expression patterns and maintaining cell type identity. The chemical modifications of histones and DNA caused by the regulated activity of chromatin-modifying enzymes such as Polycomb help establish and maintain such expression patterns. Polycomb repressive complex 2 (PRC2) is the only known methyltransferase specific for histone H3 lysine 27 (H3K27) and catalyzes its trimethylation leading to the repressive H3K27me3 mark. Structural biology has made important contributions to our understanding of the molecular mechanisms that ensure the spatiotemporal regulation of PRC2 activity and the establishment of inactive chromatin domains marked by H3K27me3. In this review, we discuss the recent structural studies that have advanced our understanding of PRC2 function, in particular the roles of intersubunit interactions in complex assembly and the regulation of methyltransferase activity, as well as the mechanism of local H3K27me3 spreading leading to repressive domains.
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