Evidence map›Paper›PMID 30451442›Full record

ReviewPolish journal of microbiology

Secondary Metabolites of Actinomycetes and their Antibacterial, Antifungal and Antiviral Properties.

Katarzyna Jakubiec-Krzesniak, Aleksandra Rajnisz-Mateusiak, Adam Guspiel, Joanna Ziemska, Jolanta Solecka

Open access · goldAbstract readReview
In one paragraph

Review in Polish journal of microbiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 200 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Actinomycetes in the spotlight: biodiversity and their role in bioremediation.World journal of microbiology & biotechnology · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Mechanism, Efficacy, and Safety of Natural Antibiotics.Antibiotics (Basel, Switzerland) · 2025
    Review
  10. Isolation of a NovelToxins · 2025
    Article
  11. Article
  12. Review
  13. Inhibitory Activity of Compounds Obtained fromPathogens (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Review
  16. Review
  17. Antimicrobial Lobophorins from Endophytic StrainMolecules (Basel, Switzerland) · 2025
    Article
  18. Review
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Katarzyna Jakubiec-KrzesniakNational Institute of Public Health - National Institute of Hygiene, Department of Environmental Health and Safety, Warsaw, Poland.
Aleksandra Rajnisz-MateusiakNational Institute of Public Health - National Institute of Hygiene, Department of Environmental Health and Safety, Warsaw, Poland.
Adam GuspielNational Institute of Public Health - National Institute of Hygiene, Department of Environmental Health and Safety, Warsaw, Poland.
Joanna ZiemskaNational Institute of Public Health - National Institute of Hygiene, Department of Environmental Health and Safety, Warsaw, Poland.
Jolanta SoleckaNational Institute of Public Health - National Institute of Hygiene, Department of Environmental Health and Safety, Warsaw, Poland.
National Institute of Public Health · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing resistance of microorganisms towards antibiotics has become a serious global problem. Therapeutics with novel chemical scaffolds and/or mechanisms of action are urgently needed to combat infections caused by multidrug resistant pathogens, including bacteria, fungi and viruses. Development of novel antimicrobial agents is still highly dependent on the discovery of new natural products. At present, most antimicrobial drugs used in medicine are of natural origin. Among the natural producers of bioactive substances, Actinobacteria continue to be an important source of novel secondary metabolites for drug application. In this review, the authors report on the bioactive antimicrobial secondary metabolites of Actinobacteria that were described between 2011 and April 2018. Special attention is paid to the chemical scaffolds, biological activities and origin of these novel antibacterial, antifungal and antiviral compounds. Arenimycin C, chromopeptide lactone RSP 01, kocurin, macrolactins A1 and B1, chaxamycin D as well as anthracimycin are regarded as the most effective compounds with antibacterial activity. In turn, the highest potency among selected antifungal compounds is exhibited by enduspeptide B, neomaclafungins A-I and kribelloside D, while ahmpatinin i Bu, antimycin A1a, and pentapeptide 4862F are recognized as the strongest antiviral agents.

Indexed as

Secondary MetabolismActinobacteriaAnti-Bacterial AgentsAntifungal AgentsAntiviral AgentsBacteriaBiological ProductsFungiMolecular StructureVirusesAnti-Bacterial AgentsAntifungal AgentsAntiviral AgentsBiological Productsactinomycetesantibacterial activitybioactivesecondary metabolitesStreptomyces sp.

Identifiers

PMID30451442
PMCPMC7256786
OpenAlexW2889601468

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.