Evidence map›Paper›PMID 30451363›Full record

ArticleJournal of cellular and molecular medicine2019

Unveiling Ga(III) phthalocyanine-a different photosensitizer in neuroblastoma cellular model.

Carolina Constantin, Andreea-Roxana Lupu, Tudor Emanuel Fertig, Mihaela Gherghiceanu, Sevinci Pop, Rodica-Mariana Ion, Monica Neagu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Carolina ConstantinImmunology Department, "Victor Babes" National Institute of Pathology, Bucharest, Romania.
Andreea-Roxana LupuImmunology Department, "Victor Babes" National Institute of Pathology, Bucharest, Romania.
Tudor Emanuel FertigThe Pathology Unit, "Victor Babes" National Institute of Pathology, Bucharest, Romania.
Mihaela GherghiceanuThe Pathology Unit, "Victor Babes" National Institute of Pathology, Bucharest, Romania.ORCID 0000-0001-6117-4328
Sevinci PopMolecular and Cellular Medicine Department, "Victor Babes" National Institute of Pathology, Bucharest, Romania.
Rodica-Mariana IonNanomedicine Research Group, National Institute for Research & Development in Chemistry and Petrochemistry, Bucharest, Romania.
Monica NeaguImmunology Department, "Victor Babes" National Institute of Pathology, Bucharest, Romania.ORCID 0000-0001-9339-2805
Institutul National Victor Babes · RONational Institute for Research and Development in Informatics - ICI Bucharest · ROUniversity of Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phthalocyanines (Pc) and their metallated derivatives are strongly considered for photodynamic therapy (PDT) possessing unique properties as possible new photosensitizers (PS). We have used toxicological assessments, real-time monitoring of cellular impedance, and imagistic measurements for assessing the in vitro dark toxicity and PDT efficacy of Ga(III)-Pc in SHSy5Y neuroblastoma cells. We have established the non-toxic concentration range of Ga(III)-Pc, a compound which shows a high intracellular accumulation, with perinuclear distribution in confocal microscopy. By choosing Ga(III)Pc non-toxic dose, we performed in vitro experimental PDT hampering cellular proliferation. Our proposed Ga(III)-Pc could complete a future PS panel for neuroblastoma alternate therapy.

Indexed as

Cell Line, TumorCell ProliferationCell SurvivalGallium RadioisotopesHumansIndolesIsoindolesNeuroblastomaPhotochemotherapyPhotosensitizing AgentsGallium RadioisotopesIndolesIsoindolesPhotosensitizing Agentsphthalocyaninegallium(III)neuroblastomaphotodynamic therapyphotosensitizerproliferationtoxicitytumourviability

Identifiers

PMID30451363
PMCPMC6349146
OpenAlexW2900781086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.