Evidence map›Paper›PMID 30451217›Full record

ArticleJournal of visualized experiments : JoVE2018

Visualize Drosophila Leg Motor Neuron Axons Through the Adult Cuticle.

Wenyue Guan, Lalanti Venkatasubramanian, Myungin Baek, Richard S Mann, Jonathan Enriquez

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. AiScience · 2023
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Wenyue GuanInstitut de Génomique Fonctionnelle de Lyon, ENS de Lyon, CNRS.
Lalanti VenkatasubramanianDepartments of Biochemistry and Molecular Biophysics, and Neuroscience, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University.
Myungin BaekNeuroscience Program, NYU School of Medicine.
Richard S MannDepartments of Biochemistry and Molecular Biophysics, and Neuroscience, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University.
Jonathan EnriquezInstitut de Génomique Fonctionnelle de Lyon, ENS de Lyon, CNRS; jonathan.enriquez@ens-lyon.fr.
Columbia University · USCentre National de la Recherche Scientifique · FRIndiana University School of MedicineInstitut de Génomique Fonctionnelle de Lyon · FR

Funding

Development and Function of an Adult Locomotion Circuit in DrosophilaR01NS070644 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANN, RICHARD S · 2010 to 2024
$6.2M
NINDS NIH HHS R01 NS070644
6 · The paper itself

Abstract

The majority of work on the neuronal specification has been carried out in genetically and physiologically tractable models such as C. elegans, Drosophila larvae, and fish, which all engage in undulatory movements (like crawling or swimming) as their primary mode of locomotion. However, a more sophisticated understanding of the individual motor neuron (MN) specification-at least in terms of informing disease therapies-demands an equally tractable system that better models the complex appendage-based locomotion schemes of vertebrates. The adult Drosophila locomotor system in charge of walking meets all of these criteria with ease, since in this model it is possible to study the specification of a small number of easily distinguished leg MNs (approximately 50 MNs per leg) both using a vast array of powerful genetic tools, and in the physiological context of an appendage-based locomotion scheme. Here we describe a protocol to visualize the leg muscle innervation in an adult fly.

Indexed as

AnimalsAxonsDrosophilaDrosophila ProteinsExtremitiesLocomotionMotor NeuronsMuscle, SkeletalDrosophila Proteins

Identifiers

PMID30451217
PMCPMC6544026
OpenAlexW2899469730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.