Evidence map›Paper›PMID 30451172›Full record

ReviewIndian journal of ophthalmology2018

Choroidal biomarkers.

Francesco Pichi, Kanika Aggarwal, Piergiorgio Neri, Paola Salvetti, Andrea Lembo, Paolo Nucci, Chui Ming Gemmy Cheung, Vishali Gupta

Open access · diamondAbstract readReview
In one paragraph

Review in Indian journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Reduced ocular perfusion after intravitreal Aflibercept and faricimab: an exploratory study for Tie2 receptor distribution in ophthalmic capillaries.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Analysis of choroidal markers of activity in pachychoroid disease spectrum.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Vogt-Koyanagi-Harada disease in a patient with extreme anisometropia.American journal of ophthalmology case reports · 2023
    Article
  13. Review
  14. Changes in choriocapillaris structure occurring in idiopathic macular hole before and after vitrectomy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Observational
  15. Article
  16. Article
  17. Article
  18. Sympathetic ophthalmia: A comprehensive update.Indian journal of ophthalmology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 5 countries.

Francesco PichiCleveland Clinic Abu Dhabi, Eye Institute, Abu Dhabi, United Arab Emirates; Cleveland Clinic Lerner College of Medicine, Case Western, Reserve University, Cleveland, OH, USA.
Kanika AggarwalAdvanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Piergiorgio NeriCleveland Clinic Abu Dhabi, Eye Institute, Abu Dhabi, United Arab Emirates.
Paola SalvettiMoorfields Eye Hospital Dubai, Dubai, United Arab Emirates.
Andrea LemboSan Giuseppe Hospital, University Eye Clinic, Milan, Italy.
Paolo NucciSan Giuseppe Hospital, University Eye Clinic, Milan, Italy.
Chui Ming Gemmy CheungSingapore National Eye Centre, Singapore Eye Research Institute, Singapore.
Vishali GuptaAdvanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ospedale San Giuseppe · ITPost Graduate Institute of Medical Education and Research · INAbu Dhabi Health Services · AEDubai Hospital · AESingapore National Eye Center · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A structurally and functionally intact choroid tissue is vitally important for the retina function. Although central retinal artery is responsible to supply the inner retina, choroidal vein network is responsible for the remaining one-third of the external part. Abnormal choroidal blood flow leads to photoreceptor dysfunction and photoreceptor death in the retina, and the choroid has vital roles in the pathophysiology of many diseases such as central serous chorioretinopathy, age-related macular degeneration, pathologic myopia, Vogt-Koyanagi-Harada disease. Biomarkers of choroidal diseases can be identified in various imaging modalities that visualize the choroid. Indocyanine green angiography enables the visualization of choroid veins under the retinal pigment epithelium and choroidal blood flow. New insights into a precise structural and functional analysis of the choroid have been possible, thanks to recent progress in retinal imaging based on enhanced depth imaging (EDI) and swept-source optical coherence tomography (SS-OCT) technologies. Long-wavelength SS-OCT enables the choroid and the choroid-sclera interface to be imaged at greater depth and to quantify choroidal thickness profiles throughout a volume scan, thus exposing the morphology of intermediate and large choroidal vessels. Finally, OCT angiography allows a dye-free evaluation of the blood flow in the choriocapillaris and in the choroid. We hereby review different imaging findings of choroidal diseases that can be used as biomarkers of activity and response to the treatment.

Indexed as

ChoroidChoroid DiseasesFluorescein AngiographyFundus OculiHumansRetinal Pigment EpitheliumTomography, Optical CoherenceChoriocapillarischoroidenhanced depth imaging optical coherence tomographyindocyanine green angiographyoptical coherence tomography angiographyswept-source optical coherence tomography

Identifiers

PMID30451172
PMCPMC6256910
OpenAlexW4232600796

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.