Evidence map›Paper›PMID 30450923›Full record

ArticleAntioxidants & redox signaling2019

NADPH Oxidase 4 Regulates Inflammation in Ischemic Heart Failure: Role of Soluble Epoxide Hydrolase.

Mark D Stevenson, Chandrika Canugovi, Aleksandr E Vendrov, Takayuki Hayami, Dawn E Bowles, Karl-Heinz Krause, Nageswara R Madamanchi, Marschall S Runge

Open access · greenAbstract read
In one paragraph

Article in Antioxidants & redox signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Aging-AssociatedJournal of the American Heart Association · 2026
    Article
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  3. Review
  4. Review
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  6. Nutritional Advantages of Walnut (Food science & nutrition · 2025
    Review
  7. Raspberry polyphenols target molecular pathways of heart failure.The Journal of nutritional biochemistry · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Nox4 Knockout Does Not Prevent Diaphragm Atrophy, Contractile Dysfunction, or Mitochondrial Maladaptation in the Early Phase Post-Myocardial Infarction in Mice.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mark D Stevenson1 Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Chandrika Canugovi1 Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Aleksandr E Vendrov1 Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Takayuki Hayami1 Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Dawn E Bowles2 Department of Surgery, Duke University School of Medicine, Durham, North Carolina.
Karl-Heinz Krause3 Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
Nageswara R Madamanchi1 Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Marschall S Runge1 Frankel Cardiovascular Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Michigan Medicine · USDuke University · USUniversity of Geneva · CH

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
OXIDATIVE STRESS AND VASCULAR AGINGP01AG024282 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SMYTH, SUSAN S. · 2004 to 2008
$7.4M
Michigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2M
Molecular Characterization of NoxA1 in VSMC NADPH Oxidase ActivationR01HL111664 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2012 to 2015
$1.5M
NHLBI NIH HHS R01 HL111664NIA NIH HHS P01 AG024282NIDDK NIH HHS P30 DK020572NIDDK NIH HHS U2C DK110768
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell LineChemokine CCL4Chemokine CCL5Disease Models, AnimalEpoxide HydrolasesGene Knockout TechniquesHeart FailureHumansMiceMyocardial IschemiaNADPH Oxidase 4RatsUp-RegulationChemokine CCL4Chemokine CCL5Epoxide HydrolasesNADPH Oxidase 4NOX4 protein, humanNox4 protein, mouseinflammationischemic heart failureLAD ligationNADPH oxidase 4soluble epoxide hydrolase

Identifiers

PMID30450923
PMCPMC6552006
OpenAlexW2900845703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.