Evidence map›Paper›PMID 30450920›Full record

ArticleBioanalysis2018

Validation and clinical application of a novel LC-MS method for quantification of dolutegravir in breast milk.

Joshua Gini, Sujan Dilly Penchala, Alieu Amara, Elizabeth Challenger, Deirdre Egan, Catriona Waitt, Mohammed Lamorde, Catherine Orrell, Landon Myer, Saye Khoo and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioanalysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04862975 (Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04862975 completednot on this mapstarted 2024, after this paper: background citation

Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana

TypeobservationalSponsorDuke UniversityRan2024 to 2025Enrolled164ConditionsLactating Women on Select DOI, Breastmilk Fed Infants of Mothers on Select DOI, HIV InfectionsArmsDolutegravir, Lamivudine, Emtricitabine, Tenofovir Disoproxil Fumarate
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joshua GiniDepartment of Molecular & Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Sujan Dilly PenchalaDepartment of Molecular & Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Alieu AmaraDepartment of Molecular & Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Elizabeth ChallengerDepartment of Molecular & Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Deirdre EganDepartment of Molecular & Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Catriona WaittDepartment of Molecular & Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Mohammed LamordeInfectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda.
Catherine OrrellDesmond Tutu HIV Foundation, Gugulethu Community Health Centre, Cape Town, South Africa.
Landon MyerCentre for Infectious Diseases Epidemiology & Research, University of Cape Town, South Africa.
Saye KhooDepartment of Molecular & Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.
Laura J ElseDepartment of Molecular & Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool, L69 3GF, UK.

Funding

Wellcome Trust 104422
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antiretroviralbreast milkclinical trialdolutegravirHIVmass spectrometrypharmacokineticsvalidation

Identifiers

PMID30450920
PMCPMC6949129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.